ArticleSleep2019
Rapid eye movement sleep mediates age-related decline in prospective memory consolidation.
Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A systematic review and meta-analysis of individual differences in naturalistic sleep quality and episodic memory performance in young and older adults.Neuroscience and biobehavioral reviews · 2021Pooled it
- Trial
- Comparison of the effect of lemborexant with placebo and zolpidem tartrate extended release on sleep architecture in older adults with insomnia disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Trial
- The Status and Associated Factors of Prospective Memory among Iranian Older Adults.Current aging science · 2026Article
- REM Sleep Misfires: Intruding Delta Waves Forecast Tau, Amyloid, and Forgetting in Aging.bioRxiv : the preprint server for biology · 2025Article
- Associations between sleep quality, plasma neurofilament light, and cognition in older adults without dementia.Translational psychiatry · 2025Article
- The influence of intentions on dream content.Sleep advances : a journal of the Sleep Research Society · 2024Article
- The Importance of Sleep for Successful Neurorehabilitation after Stroke.Sleep science (Sao Paulo, Brazil) · 2023Review
- Longitudinal trajectories of spectral power during sleep in middle-aged and older adults.Aging brain · 2023Article
- Increased Rapid Eye Movement Sleep Is Associated With a Reduced Risk of Heart Failure in Middle-Aged and Older Adults.Frontiers in cardiovascular medicine · 2022Article
- Sleep-dependent memory consolidation in breast cancer: Use of a virtual reality prospective memory task.Frontiers in neuroscience · 2022Article
- Nighttime sleep benefits the prospective component of prospective memory.Memory & cognition · 2021Article
- Sleep spectral power correlates of prospective memory maintenance.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Sleep disturbances are associated with cortical and subcortical atrophy in alcohol use disorder.Translational psychiatry · 2021Article
- Sleep, Prospective Memory, and Immune Status among People Living with HIV.International journal of environmental research and public health · 2021Article
- Sleep and Prospective Memory: A Retrospective Study in Different Clinical Populations.International journal of environmental research and public health · 2020Article
- Prospective Memory, Sleep, and Age.Brain sciences · 2020Article
- Classical music, educational learning, and slow wave sleep: A targeted memory reactivation experiment.Neurobiology of learning and memory · 2020Article
- Are subjective sleepiness and sleep quality related to prospective memory?Cognitive research: principles and implications · 2020Article
- Effects of Sleep and Age on Prospective Memory Consolidation: A Walk in a Virtual Museum.Clocks & sleep · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesProspective memory, or remembering to execute future intentions, accounts for half of everyday forgetting in older adults. Sleep intervals benefit prospective memory consolidation in young adults, but it is unknown whether age-related changes in slow wave activity, sleep spindles, and/or rapid eye movement (REM) sleep mediate hypothesized effects of aging on prospective memory consolidation.
methodsAfter an adaptation night, 76 adults aged 18-84 completed two experimental nights of in-laboratory polysomnography recording. In the evening, participants encoded and practiced a prospective memory task and were tested the next morning. On a counterbalanced night, they encoded and practiced a control task, and were tested the following morning.
resultsIncreasing age predicted worse prospective memory consolidation (r = -.34), even when controlling for encoding, speed, and control-task performance (all ps < .05). Frontal delta power, slow oscillations, and spindle density were not related to prospective memory consolidation. REM sleep duration, however, explained significant variance in prospective memory consolidation when controlling for age (∆R2 = .10). Bootstrapping mediation showed that less REM sleep significantly mediated the aging effect on prospective memory consolidation [b = -.0016, SE = 0.0009 (95% confidence interval [CI] = -0.0042 to -0.0004)]. REM sleep continued to mediate 24.29% of the total effect of age on prospective memory after controlling for numerous demographic, cognitive, mental health, and sleep variables.
conclusionAge-related variance in REM sleep is informative to how prospective memory consolidation changes with increasing age. Future work should consider how both REM sleep and slow wave activity contribute, perhaps in a sequential or dynamic manner, to preserving cognitive functioning with increasing age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.