Evidence map›Paper›PMID 30859901›Full record

ArticleAutophagy2019

Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation.

Brittany L Baechler, Darin Bloemberg, Joe Quadrilatero

Abstract read
In one paragraph

Article in Autophagy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 1 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 1 synthesis or guideline pooled it, 277 citations in OpenAlex.

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  18. Deficiency ofZoological research · 2026
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110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brittany L Baechlera Department of Kinesiology, University of Waterloo , Waterloo , Ontario , Canada.
Darin Bloemberga Department of Kinesiology, University of Waterloo , Waterloo , Ontario , Canada.
Joe Quadrilateroa Department of Kinesiology, University of Waterloo , Waterloo , Ontario , Canada.ORCID 0000-0002-9304-3557
University of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macroautophagy/autophagy is a degradative process essential for various cellular processes. We previously demonstrated that autophagy-deficiency causes myoblast apoptosis and impairs myotube formation. In this study, we continued this work with particular emphasis on mitochondrial remodelling and stress/apoptotic signaling. We found increased (p < 0.05) autophagic (e.g., altered LC3B levels, increased ATG7, decreased SQSTM1) and mitophagic (e.g., BNIP3 upregulation, mitochondrial localized GFP-LC3 puncta, and elevated mitochondrial LC3B-II) signaling during myoblast differentiation. shRNA-mediated knockdown of ATG7 (sh

Indexed as

AnimalsApoptosisAutophagy-Related Protein 7Caspase 3Caspase 9Cell DifferentiationCell LineEndoplasmic ReticulumMembrane ProteinsMiceMicrotubule-Associated ProteinsMitochondriaMitochondrial ProteinsMitophagyMuscle DevelopmentMuscle, SkeletalAtg7 protein, mouseAutophagy-Related Protein 7BNip3 protein, mouseCasp3 protein, mouseCasp9 protein, mouseCaspase 3Caspase 9Map1lc3b protein, mouseMembrane ProteinsMicrotubule-Associated ProteinsMitochondrial ProteinsReactive Oxygen SpeciesApoptosisautophagycaspase 9differentiationmitochondriamitophagymyogenesisoxidative stressskeletal muscle

Identifiers

PMID30859901
PMCPMC6693454
OpenAlexW2921170434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.