Evidence map›Paper›PMID 30859703›Full record

ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2019

Genetic association and functional characterization of MCPH1 gene variation in bipolar disorder and schizophrenia.

Mariam M Al Eissa, Sally I Sharp, Niamh L O'Brien, Alessia Fiorentino, Nicholas J Bass, David Curtis, Andrew McQuillin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Effects of Psychotropic Drugs on Ribosomal Genes and Protein Synthesis.International journal of molecular sciences · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mariam M Al EissaMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
Sally I SharpMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
Niamh L O'BrienMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
Alessia FiorentinoMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
Nicholas J BassMolecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
David Curtis
Andrew McQuillinDepartment of Genetics, Evolution and Environment, UCL Genetics Institute, University College London, London, UK.ORCID 0000-0003-1567-2240
University College London · GBInstitute of Genetics · HU

Funding

A Large-Scale Schizophrenia Association Study in SwedenR01MH077139 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2007 to 2018
$9.9M
Whole genome sequencing of bipolar disorder and schizophreniaRC2MH089905 · NIMH · BROAD INSTITUTE, INC. · PI PURCELL, SHAUN M, SKLAR, PAMELA · 2009 to 2010
$6.2M
Medical Research Council G0500791Medical Research Council G0701007Medical Research Council G0801038Medical Research Council G1000708Medical Research Council G9623693NNeuroscience Research Charitable TrustNIMH NIH HHS R01 MH077139NIMH NIH HHS RC2 MH089905Stanley Center for Psychiatric Research at the Broad InstituteStanley FoundationStanley Medical Research InstituteSwedish Research Council 2009-4959Swedish Research Council 2011-4659University College London Hospitals NHS Foundation Trust NIHR BRCWellcome TrustWellcome Trust WT091310
6 · The paper itself

Abstract

A rare microcephalin 1 gene (MCPH1) variant rs61749465A>G (p.Asp61Gly) with prior evidence for association with schizophrenia (p = 3.78 × 10

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseGenetic VariationAllelesBipolar DisorderCell Cycle ProteinsCytoskeletal ProteinsDNA DamageGene Expression RegulationHEK293 CellsHumansRNA, MessengerRNA StabilitySchizophreniaCell Cycle ProteinsCytoskeletal ProteinsMCPH1 protein, humanRNA, Messengerallelic associationbipolar disorderMCPH1RNA sequencingschizophrenia

Identifiers

PMID30859703
PMCPMC8005923
OpenAlexW2921496172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.