ArticleClinical implant dentistry and related research2019
Evaluation of a novel oral mucosa in vitro implantation model for analysis of molecular interactions with dental abutment surfaces.
Article in Clinical implant dentistry and related research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Three dimensional (3D) gingival models in periodontal research: a systematic review.Journal of materials science. Materials in medicine · 2023Pooled it
- Differential Attachment of Engineered Oral Soft Tissues to Implant Surfaces.Dentistry journal · 2026Article
- Impact of Zirconia and Titanium Implant Surfaces of Different Roughness on Oral Epithelial Cells.Dentistry journal · 2026Article
- Evaluation of Implant Abutment-Soft Tissue Attachment Using 3D Tissue-Engineered Oral Mucosa: A Systematic Review.International journal of dentistry · 2026Review
- Review
- Clinical and Esthetic Outcomes of Anodized Titanium Abutments: A Systematic Review of Randomized Controlled Trials.Clinical, cosmetic and investigational dentistry · 2025Review
- Bioengineering the Junctional Epithelium in 3D Oral Mucosa Models.Journal of functional biomaterials · 2024Review
- Bioengineering from the laboratory to clinical translation in oral and maxillofacial reconstruction.The Saudi dental journal · 2024Review
- The integration of peri-implant soft tissues around zirconia abutments: Challenges and strategies.Bioactive materials · 2023Review
- Contour Analysis of Three-Dimensional Peri-Implant Mucosal Model as an Endpoint Analysis of Photofunctionalization Effects on Implant Abutment Materials.Materials (Basel, Switzerland) · 2023Article
- Influence of Surface Characteristics of TiOMaterials (Basel, Switzerland) · 2023Review
- Expression of Interleukin-1β and Histological Changes of the Three-Dimensional Oral Mucosal Model in Response to Yttria-Stabilized Nanozirconia.Materials (Basel, Switzerland) · 2023Article
- Macromolecular crowding regulates matrix composition and gene expression in human gingival fibroblast cultures.Scientific reports · 2023Article
- Junctional epithelium and hemidesmosomes: Tape and rivets for solving the "percutaneous device dilemma" in dental and other permanent implants.Bioactive materials · 2022Review
- The Effect of UV Treatment on Surface Contact Angle, Fibroblast Cytotoxicity, and Proliferation with Two Types of Zirconia-Based Ceramics.International journal of environmental research and public health · 2022Article
- Oral mucosa equivalents, prevascularization approaches, and potential applications.Connective tissue research · 2022Review
- Organotypic in vitro block culture model to investigate tissue-implant interface. An experimental study on pig mandible.Journal of materials science. Materials in medicine · 2021Article
- Article
- An In-Vitro Analysis of Peri-Implant Mucosal Seal Following Photofunctionalization of Zirconia Abutment Materials.Biomedicines · 2021Article
- One-Piece Titanium Implants: Retrospective Case Series.Case reports in dentistry · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAbutment surfaces are being designed to promote gingival soft tissue attachment and integration. This forms a seal around prosthetics and consequently ensures long-term implant survival. New scalable and reproducible models are necessary to evaluate and quantify the performance of these surfaces. PURPOSE: To evaluate a novel implantation model by histomorphometric and immunohistochemical characterization of the interactions between human oral gingival tissue and titanium abutments with either novel anodized or conventional machined surface. MATERIALS AND
methodsAbutments were inserted into an organotypic reconstructed human gingiva (RHG) model consisting of differentiated gingival epithelium cells on a fibroblast populated lamina propria hydrogel following a tissue punch. Epithelial attachment, down-growth along the abutment surface, and phenotype were assessed via histomorphology, scanning electron microscopy, and immunohistochemistry 10 days after implantation.
resultsThe down-growing epithelium transitioned from a gingival margin to a sulcular and junctional epithelium. The sulcus depth and junctional epithelial length were similar to previously reported pre-clinical and clinical lengths. A collagen IV/laminin 5 basement membrane formed between the epithelium and the underlying connective tissue. The RHG expanded in thickness approximately 2-fold at the abutment surface. The model allowed the evaluation of protein expression of adhering soft tissue cells for both tested abutments.
conclusionsThe RHG model is the first in vitro 3D model to enable the assessment of not only human epithelial tissue attachment to dental abutments but also the expression of protein markers involved in soft tissue attachment and integration. The two abutments showed no noticeable difference in epithelial attachment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.