Evidence map›Paper›PMID 30859677›Full record

ReviewJournal of magnetic resonance imaging : JMRI2020

Liver fibrosis imaging: A clinical review of ultrasound and magnetic resonance elastography.

Yingzhen N Zhang, Kathryn J Fowler, Arinc Ozturk, Chetan K Potu, Ashley L Louie, Vivian Montes, Walter C Henderson, Kang Wang, Michael P Andre, Anthony E Samir and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of magnetic resonance imaging : JMRI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 5 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Applications of elastography in operative neurosurgery: A systematic review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022
    Pooled it
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  14. Imaging Evaluation for Steatotic Liver Disease.Korean journal of radiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yingzhen N ZhangLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California, USA.
Kathryn J FowlerLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California, USA.
Arinc OzturkCenter for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Chetan K PotuLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California, USA.
Ashley L LouieLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California, USA.
Vivian MontesLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California, USA.
Walter C HendersonLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California, USA.
Kang WangLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California, USA.
Michael P AndreDepartment of Radiology, University of California, San Diego, La Jolla, California, USA.
Anthony E SamirCenter for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Claude B SirlinLiver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California, USA.
University of California, San Diego · USUniversity of California System · USMassachusetts General Hospital · US

Funding

Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLDR01DK106419 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT, SIRLIN, CLAUDE B · 2015 to 2019
$3.4M
Traning Clinical Scientists in Radiological ImagingT32EB005970 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric Y Chang, Rebecca Ann Rakow-Penner · 2007 to 2026
$3.2M
Development of a Machine Learning Model to Integrate Clinical, Laboratory, Sonographic, and Elastographic Data for Noninvasive Liver Tissue Characterization in NAFLDR01DK119860 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAMIR, ANTHONY EDWARD · 2019 to 2023
$2.3M
Detection of Liver Fibrosis Using IVIM Diffusion and DCE MRI in HCVR01DK087877 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TAOULI, BACHIR · 2010 to 2014
$1.8M
Reducing Variability in Hepatic Shear Wave ElastographyK23EB020710 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI SAMIR, ANTHONY EDWARD · 2016 to 2019
$781k
NIBIB NIH HHS K23 EB020710NIBIB NIH HHS T32 EB005970NIDDK NIH HHS R01 DK087877NIDDK NIH HHS R01 DK088925NIDDK NIH HHS R01 DK106419NIDDK NIH HHS R01 DK119860
6 · The paper itself

Abstract

Liver fibrosis is a histological hallmark of most chronic liver diseases, which can progress to cirrhosis and liver failure, and predisposes to hepatocellular carcinoma. Accurate diagnosis of liver fibrosis is necessary for prognosis, risk stratification, and treatment decision-making. Liver biopsy, the reference standard for assessing liver fibrosis, is invasive, costly, and impractical for surveillance and treatment response monitoring. Elastography offers a noninvasive, objective, and quantitative alternative to liver biopsy. This article discusses the need for noninvasive assessment of liver fibrosis and reviews the comparative advantages and limitations of ultrasound and magnetic resonance elastography techniques with respect to their basic concepts, acquisition, processing, and diagnostic performance. Variations in clinical contexts of use and common pitfalls associated with each technique are considered. In addition, current challenges and future directions to improve the diagnostic accuracy and clinical utility of elastography techniques are discussed. Level of Evidence: 5 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2020;51:25-42.

Indexed as

Elasticity Imaging TechniquesHumansLiverLiver CirrhosisMagnetic Resonance Imaging

Identifiers

PMID30859677
PMCPMC6742585
OpenAlexW2920928508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.