ArticleBiometrics2019
High dimensional mediation analysis with latent variables.
Article in Biometrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- The Role of the Oral Microbiome in Circulating Metabolic Biomarkers and the Influence of Air Pollution.Oral diseases · 2026Article
- MELODY: Mediation Analysis in Logistic Regression for High-Dimensional Mediators and a Binary Outcome.Genetic epidemiology · 2026Article
- Bayesian Variable Selection for High-Dimensional Mediation Analysis: Application to Metabolomics Data in Epidemiological Studies.Statistics in medicine · 2026Article
- Mediation analysis with graph mediator.Biostatistics (Oxford, England) · 2025Article
- MELODY: Mediation Analysis in Logistic Regression for High-Dimensional Mediators and a Binary Outcome.bioRxiv : the preprint server for biology · 2025Article
- HILAMA: High-dimensional multi-omics mediation analysis with latent confounding.BMC medical research methodology · 2025Article
- Causal Mediation Analysis for Integrating Exposure, Genomic, and Phenotype Data.Annual review of statistics and its application · 2025Article
- Article
- Mediation analysis in longitudinal study with high-dimensional methylation mediators.Briefings in bioinformatics · 2024Article
- A Bayesian nonparametric approach for multiple mediators with applications in mental health studies.Biostatistics (Oxford, England) · 2024Article
- Mediation analysis using incomplete information from publicly available data sources.Statistics in medicine · 2024Article
- A new framework for exploratory network mediator analysis in omics data.Genome research · 2024Article
- INTEGRATING INCOMPLETE DATA FOR MEDIATION ANALYSIS.Statistica Sinica · 2024Article
- Imaging mediation analysis for longitudinal outcomes: a case study of childhood brain tumor survivorship.Statistics and its interface · 2024Article
- An extension of latent unknown clustering integrating multi-omics data (LUCID) incorporating incomplete omics data.Bioinformatics advances · 2024Article
- Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons.PLoS genetics · 2023Article
- Article
- The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Review
- Bayesian network mediation analysis with application to the brain functional connectome.Statistics in medicine · 2022Article
- HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data.BMC bioinformatics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
We propose a model for high dimensional mediation analysis that includes latent variables. We describe our model in the context of an epidemiologic study for incident breast cancer with one exposure and a large number of biomarkers (i.e., potential mediators). We assume that the exposure directly influences a group of latent, or unmeasured, factors which are associated with both the outcome and a subset of the biomarkers. The biomarkers associated with the latent factors linking the exposure to the outcome are considered "mediators." We derive the likelihood for this model and develop an expectation-maximization algorithm to maximize an L1-penalized version of this likelihood to limit the number of factors and associated biomarkers. We show that the resulting estimates are consistent and that the estimates of the nonzero parameters have an asymptotically normal distribution. In simulations, procedures based on this new model can have significantly higher power for detecting the mediating biomarkers compared with the simpler approaches. We apply our method to a study that evaluates the relationship between body mass index, 481 metabolic measurements, and estrogen-receptor positive breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.