Trial reportEuropean journal of nutrition2020
Combined choline and DHA supplementation: a randomized controlled trial.
Trial report in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02509728 (Nahrungsergänzung Mit Cholin- Und Docosahexaensäure Bei Sehr Unreifen Frühgeborenen), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nahrungsergänzung Mit Cholin- Und Docosahexaensäure Bei Sehr Unreifen Frühgeborenen
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Effect of enteral supplementation of DHA with or without ARA in preterm infants: a meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2025Pooled it
- The use of choline supplementation in premature newborns: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025Pooled it
- Choline supplementation in preterm infants: effects of four different supplements on choline plasma concentrations.European journal of nutrition · 2026Trial
- Trial
- Different choline supplement metabolism in adults using deuterium labelling.European journal of nutrition · 2023Trial
- Choline supplementation for preterm infants: metabolism of four Deuterium-labeled choline compounds.European journal of nutrition · 2023Trial
- Trial
- Choline and Its Companions: Inter-Related Roles of Choline and B Vitamins in Fetal Development and Offspring Health.Nutrients · 2026Review
- Depressive Symptoms Associated with Decreased Choline Intake in Lactating Mothers of Preterm Infants.Nutrients · 2026Article
- Choline supplementation in classic homocystinuria: impact on homocysteine and hepatic steatosis.Pediatric research · 2026Article
- Choline-An Essential Nutrient with Health Benefits and a Signaling Molecule.International journal of molecular sciences · 2025Review
- Choline in Pediatric Nutrition: Assessing Formula, Fortifiers and Supplements Across Age Groups and Clinical Indications.Nutrients · 2025Article
- Untargeted metabolomics reveals stage-specific metabolic signatures in yak colostrum, transitional milk and mature milk.Food chemistry: X · 2025Article
- Article
- Is choline deficiency an unrecognized factor in necrotizing enterocolitis of preterm infants?Pediatric research · 2024Review
- Evidence and Perspectives for Choline Supplementation during Parenteral Nutrition-A Narrative Review.Nutrients · 2024Review
- Phospholipid supplementation inhibits male and female odor discrimination in mice.Frontiers in behavioral neuroscience · 2024Article
- Choline and Fish Oil Can Improve Memory of Mice through Increasing Brain DHA Level.Foods (Basel, Switzerland) · 2023Article
- The Effect of Dietary Phospholipids on the Ultrastructure and Function of Intestinal Epithelial Cells.International journal of molecular sciences · 2023Article
- Choline supplements: An update.Frontiers in endocrinology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveCholine and docosahexaenoic acid (DHA) are essential nutrients for preterm infant development. They are metabolically linked via phosphatidylcholine (PC), a constitutive plasma membrane lipid and the major transport form of DHA in plasma. Plasma choline and DHA-PC concentrations rapidly decline after preterm birth. To improve preterm infant nutrition, we evaluated combined compared to exclusive choline and DHA supplementation, and standard feeding.
designRandomized partially blinded single-center trial.
settingNeonatal tertiary referral center in Tübingen, Germany. PATIENTS: 24 inborn preterm infants < 32 week postmenstrual age.
interventionsStandard nutrition (control) or, additionally, enteral choline (30 mg/kg/day), DHA (60 mg/kg/day), or both for 10 days. Single enteral administration of 3.6 mg/kg [methyl-D
main outcome measuresPrimary outcome variable was plasma choline following 7 days of supplementation. Deuterated and unlabeled choline metabolites, DHA-PC, and other PC species were secondary outcome variables.
resultsCholine supplementation increased plasma choline to near-fetal concentrations [35.4 (32.8-41.7) µmol/L vs. 17.8 (16.1-22.4) µmol/L, p < 0.01] and decreased D
conclusions30 mg/kg/day additional choline supplementation increases plasma choline to near-fetal concentrations, dilutes the D
trial registrationclinicaltrials.gov. Identifier: NCT02509728.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.