Evidence map›Paper›PMID 30859351›Full record

ReviewClinical and experimental nephrology2019

Novel tubular-glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017.

Kazuhiro Hasegawa

Open access · hybridAbstract readReview
In one paragraph

Review in Clinical and experimental nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Ability of NAD and Sirt1 to epigenetically suppress albuminuria.Clinical and experimental nephrology · 2024
    Review
  3. International journal of molecular sciences · 2024
    Article
  4. Article
  5. Review
  6. Review
  7. Folic acid-induced animal model of kidney disease.Animal models and experimental medicine · 2021
    Review
  8. Article
  9. Article
  10. Decreased Urinary Levels ofInternational journal of molecular sciences · 2020
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kazuhiro HasegawaDepartment of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8584, Japan. kazuhiro@z2.keio.jp.
Keio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tubules interact with glomeruli, which are composed of podocytes, parietal epithelial cells, mesangial cells, and glomerular endothelial cells. Glomerular-tubular balance and tubuloglomerular feedback are the two components of the tubular-glomerular interplay, which has been demonstrated to play roles in physiological renal function and in diabetic kidney disease (DKD), in which proteins leaking from glomeruli arrive at tubular regions, leading to further tubular injury caused by the accumulation of proteinuria-inducing reactive oxygens species and various cytokines. In the current review, we present our recent work identifying a novel tubular-glomerular interplay in DKD mediated by sirtuin 1 and nicotinamide mononucleotide.

Indexed as

AnimalsAwards and PrizesClaudin-1Diabetic NephropathiesEpigenesis, GeneticGene Expression RegulationGlucose Transporter Type 2HumansKidney GlomerulusKidney TubulesNADNicotinamide MononucleotideSignal TransductionSirtuin 1Sodium-Glucose Transporter 2Claudin-1CLDN1 protein, humanGlucose Transporter Type 2NADNicotinamide MononucleotideSIRT1 protein, humanSirtuin 1SLC2A2 protein, humanSLC5A2 protein, humanSodium-Glucose Transporter 2Diabetic kidney diseaseNicotinamide mononucleotideSirtuin 1Tubuloglomerular feedback

Identifiers

PMID30859351
PMCPMC6647828
OpenAlexW2920932117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.