Evidence map›Paper›PMID 30859334›Full record

ArticlePsychopharmacology2019

GABAergic imbalance is normalized by dopamine D

Arturo Gálvez-Rosas, Alberto Avila-Luna, Margarita Valdés-Flores, Sergio Montes, Antonio Bueno-Nava

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. The Interaction of Histamine HPharmaceuticals (Basel, Switzerland) · 2024
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  3. Altered Expression andCurrent neuropharmacology · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Arturo Gálvez-RosasLab. Neurofisiología Química de la Discapacidad, División de Neurociencias, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, SSa, Calz. México-Xochimilco 289, Col. Arenal de Guadalupe, 14389, Mexico City, Mexico.
Alberto Avila-LunaLab. Neurofisiología Química de la Discapacidad, División de Neurociencias, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, SSa, Calz. México-Xochimilco 289, Col. Arenal de Guadalupe, 14389, Mexico City, Mexico.
Margarita Valdés-FloresDepartamento de Genética y Medicina Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, SSa, Calz. México-Xochimilco 289, Col. Arenal de Guadalupe, 14389, Mexico City, Mexico.
Sergio MontesDepartamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, SSa, Insurgentes Sur 3877, 14269, Mexico City, Mexico.
Antonio Bueno-NavaLab. Neurofisiología Química de la Discapacidad, División de Neurociencias, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, SSa, Calz. México-Xochimilco 289, Col. Arenal de Guadalupe, 14389, Mexico City, Mexico. abueno@inr.gob.mx.
Instituto Nacional de Rehabilitación · MXInstituto Nacional de Neurología y Neurocirugía · MX

Funding

Consejo Nacional de Ciencia y Tecnología (Conacyt), Mexico. 288512
6 · The paper itself

Abstract

rationaleThe sensorimotor cortex and the striatum are interconnected by the corticostriatal pathway, suggesting that cortical injury alters the striatal function, which may be modulated by dopamine.

objectivesWe studied whether the activation of dopamine D

methodsThe D

resultsGABAergic imbalance in the striatum contralateral to the injury site was normalized by the administration of the D

conclusionThe reversal of the GABAergic imbalance in the striatum contralateral to the cortical injury can be modulated by extrastriatal D

Indexed as

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsBenzazepinesCorpus StriatumDopamineDopamine AgonistsDopamine Antagonistsgamma-Aminobutyric AcidMaleNeostriatumRatsRats, WistarReceptors, Dopamine D1Recovery of FunctionSensorimotor Cortex2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineBenzazepinesDopamineDopamine AgonistsDopamine Antagonistsgamma-Aminobutyric AcidReceptors, Dopamine D1SCH 23390Cortical injuryD1 receptorsDopamineGABAGlutamatemRNAStriatum

Identifiers

PMID30859334
OpenAlexW2922012803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.