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ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

High adherence of patients with multiple myeloma who receive treatment with immunomodulatory drugs (IMIDS) in hematology/oncology group practices in Germany.

Stefan Feiten, Geothy Chakupurakal, Hans Peter Feustel, Michael Maasberg, Burkhard Otremba, Peter Ehscheidt, Manfred Hensel, Richard Hansen, Rudolf Weide

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefan FeitenInstitut für Versorgungsforschung in der Onkologie, Koblenz, Germany. s.feiten@invo-koblenz.de.ORCID http://orcid.org/0000-0003-4737-7393
Geothy ChakupurakalPraxisklinik für Hämatologie und Onkologie, Koblenz, Germany.
Hans Peter FeustelOnkologische Schwerpunktpraxis, Speyer, Germany.
Michael MaasbergOnkologische Gemeinschaftspraxis, Mayen, Germany.
Burkhard OtrembaOnkologische Praxis, Oldenburg/Delmenhorst, Germany.
Peter EhscheidtOnkologische Praxis Dr. Ehscheidt, Neuwied, Germany.
Manfred HenselMannheimer Onkologie Praxis, Mannheim, Germany.
Richard HansenOnkologische Schwerpunktpraxis, Kaiserslautern, Germany.
Rudolf WeidePraxisklinik für Hämatologie und Onkologie, Koblenz, Germany.

Funding

Celgene GmbH none
6 · The paper itself

Abstract

purposeImmunomodulatory drugs (IMIDS) have changed the treatment and outcome of patients suffering from multiple myeloma. However, with the oral administration adherence becomes an issue. Since there is no "gold standard" in measuring adherence, we assessed the adherence of myeloma patients with the help of different data sources.

methodsAll patients who have been receiving IMIDS for at least 3 months were eligible. Computer assisted personal interviews of patients and, if possible, their caregivers were carried out. Attending oncologists evaluated the patient's adherence with the help of a standardized questionnaire. In addition, a retrospective analysis of prescription data was conducted. All data were analyzed statistically using SPSS.

resultsOne hundred myeloma patients, 35% female, 65% male, with a median age of 70 years (37-86) were interviewed. Prescription data could be evaluated in terms of adherence in 78 patients (78%), 56 caregivers could be questioned (56%). Ninety-seven percent of patients rated themselves as adherent in taking IMIDS. Data from treating oncologists, caregivers and prescriptions supported this result. IMID therapies were rated as very effective and significant, toxicities were acceptable and dosing regimens simple/uncomplicated.

conclusionsMyeloma patients seem to be highly adherent to IMID treatments.

Indexed as

Drug MonitoringAdultAgedAged, 80 and overFemaleGermanyGroup PracticeHumansImmunomodulationMaleMiddle AgedMultiple MyelomaRetrospective StudiesAdherenceComplianceIMIDSImmunomodulatory drugsMultiple myelomaOutpatient treatment

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.