Evidence map›Paper›PMID 30859303›Full record

ArticleArchives of orthopaedic and trauma surgery2019

Correlation of histological and microbiological findings in septic and aseptic knee implant failure.

Y Inagaki, Y Uchihara, M Munemoto, M Scarborough, C A F Dodd, C L M H Gibbons, Y Tanaka, N A Athanasou

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Article in Archives of orthopaedic and trauma surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Y InagakiNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Clinical Laboratory Services, University of Oxford, Nuffield Orthopaedic Centre, OX3 7HE, Oxford, UK.
Y UchiharaNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Clinical Laboratory Services, University of Oxford, Nuffield Orthopaedic Centre, OX3 7HE, Oxford, UK.
M MunemotoNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Clinical Laboratory Services, University of Oxford, Nuffield Orthopaedic Centre, OX3 7HE, Oxford, UK.
M ScarboroughNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Clinical Laboratory Services, University of Oxford, Nuffield Orthopaedic Centre, OX3 7HE, Oxford, UK.
C A F DoddNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Clinical Laboratory Services, University of Oxford, Nuffield Orthopaedic Centre, OX3 7HE, Oxford, UK.
C L M H GibbonsNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Clinical Laboratory Services, University of Oxford, Nuffield Orthopaedic Centre, OX3 7HE, Oxford, UK.
Y TanakaDepartment of Orthopaedic Surgery, Nara Medical University, Shijocho 840, 634-8521, Kashihara, Japan.
N A AthanasouNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Clinical Laboratory Services, University of Oxford, Nuffield Orthopaedic Centre, OX3 7HE, Oxford, UK. nick.athanasou@ndorms.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Musculoskeletal Infection Society (MSIS) has defined specific clinical and laboratory criteria for the diagnosis of periprosthetic joint infection (PJI). In this study we assessed the diagnostic utility of MSIS microbiological and histological criteria for PJI in 138 cases of septic and aseptic knee implant failure. MATERIALS AND

methodsIntra-operative samples from 60 cases of knee septic implant failure (SIF) and 78 cases of aseptic implant failure (AIF), defined on the basis of clinical, laboratory and operative findings/surgical management, were analysed microbiologically and histologically. Findings were correlated with the final clinical diagnosis and the specificity, sensitivity, accuracy, positive and negative predictive value of MSIS microbiological and histological criteria for knee PJI were assessed.

results80% of SIF cases showed culture of the same organism from two or more samples (ie MSIS microbiological criteria for definite PJI); 8.3% grew an organism from one sample, and 11.7% showed no growth from any sample. 23.1% of AIF cases grew an organism from one sample and 76.9% showed no growth from any sample. MSIS histological criteria for PJI identified 96.7% of SIF cases. The sensitivity, specificity, accuracy and positive and negative predictive value of MSIS histological criteria for PJI were 96.7%, 100%, 98.6%, 100% and 97.5%, respectively. MSIS microbiological and histological criteria identified all AIF cases.

conclusionsKnee PJI is more often identified by current MSIS histological than microbiological criteria. A significant proportion of SIF cases show either no growth or growth of an organism from only one sample. AIF is identified by both MSIS microbiological and histological criteria. Correlation of clinical, radiological and laboratory findings is required for the diagnosis of knee PJI.

Indexed as

Knee JointKnee ProsthesisAdultAgedAged, 80 and overArthroplasty, Replacement, KneeFemaleHumansMaleMiddle AgedOsteoarthritis, KneeProsthesis FailureProsthesis-Related InfectionsArthroplastyHistologyInfectionKneeMicrobiologyMSIS

Identifiers

PMID30859303
PMCPMC6469672

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