Evidence map›Paper›PMID 30859243›Full record

Observational studyEuropean journal of clinical pharmacology2019

Tacrolimus exposure early after lung transplantation and exploratory associations with acute cellular rejection.

David R Darley, Lilibeth Carlos, Stefanie Hennig, Zhixin Liu, Richard Day, Allan R Glanville

Open access · bronzeAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Weight,Current pharmaceutical design · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

David R DarleyLung Transplant Unit, St Vincent's Hospital Darlinghurst, Sydney, Australia. David.Darley@svha.org.au.ORCID http://orcid.org/0000-0002-9721-101X
Lilibeth CarlosDepartment of Pharmacy, St Vincent's Hospital Darlinghurst, Sydney, Australia.
Stefanie HennigSchool of Pharmacy, University of Queensland, Brisbane, Australia.
Zhixin LiuDepartment of Statistics, University of New South Wales, Kensington, Australia.
Richard DayUNSW Medicine, St Vincent's Hospital Clinical School, Sydney, Australia.
Allan R GlanvilleLung Transplant Unit, St Vincent's Hospital Darlinghurst, Sydney, Australia.
St Vincent's Hospital Sydney · AUSt Vincent's Hospital Melbourne · AUThe University of Queensland · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo (i) describe tacrolimus (TAC) pre-dose concentrations (C

methodsTAC whole blood concentration-time profiles and transbronchial biopsies were performed prospectively at weeks 3, 6 and 12 after lung transplantation. The TAC pre-dose concentration (C

resultsEighteen patients provided 377 TAC whole blood concentrations. Considerable variability around the median (IQR) CL/F

conclusionMonitoring TAC C

Indexed as

Lung TransplantationAcute DiseaseAdministration, OralAdultFemaleGraft RejectionHumansImmunosuppressive AgentsMaleMiddle AgedTacrolimusImmunosuppressive AgentsTacrolimusClearanceExposureLung transplantationRejectionTacrolimus

Identifiers

PMID30859243
OpenAlexW2921085487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.