Evidence map›Paper›PMID 30859221›Full record

ArticleRheumatology (Oxford, England)2019

Development and validation of a patient-reported gout attack intensity score for use in gout clinical studies.

Carly A Janssen, Martijn A H Oude Voshaar, Peter M Ten Klooster, Harald E Vonkeman, Mart A F J van de Laar

Open access · bronzeAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Pipeline Therapies for Gout.Current rheumatology reports · 2024
    Review
  3. Article
  4. Review: Outcome measures in calcium pyrophosphate deposition.Best practice & research. Clinical rheumatology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Carly A JanssenArthritis Center Twente, Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.
Martijn A H Oude VoshaarArthritis Center Twente, Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.
Peter M Ten KloosterArthritis Center Twente, Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.
Harald E VonkemanArthritis Center Twente, Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.
Mart A F J van de LaarArthritis Center Twente, Department of Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.
University of Twente · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveInflammation-related symptoms such as pain, swelling and tenderness of the affected joint are frequently assessed using 5-point diary rating scales in gout clinical trials. Combining these into a single gout attack symptom intensity score may be a useful summary measure for these data, which is potentially more responsive to change compared with the individual components. The objective of this study was to develop a patient-reported gout flare intensity score, the Gout Attack Intensity Score (GAIS), for use in clinical studies, that includes components for gout-related pain, swelling and tenderness.

methodsData from a randomized controlled trial comparing anakinra to standard of care for the treatment of acute gout attacks were used for this study. A 7-day flare diary was completed by patients, including questions relating to intensity of pain, swelling and tenderness (5-point rating scales). Scalability of these items was assessed using Mokken Scale Analysis, and reliability using greatest lower bound reliability coefficients. Known-groups validity was evaluated, as well as the responsiveness to change and the presence of floor and ceiling effects.

resultsScalability of the single items was supported, and GAIS scores were reliable (greatest lower bound >0.80). GAIS scores demonstrated responsiveness to change with high effect sizes (>0.8), and discriminated better between responders and non-responders compared with its single-item components. No floor and ceiling effects were found.

conclusionThe GAIS seems to be a reliable and responsive instrument for assessing patient-reported gout attack intensity that may be used in gout clinical studies.

Indexed as

Patient Reported Outcome MeasuresSeverity of Illness IndexSymptom Flare UpAgedAnti-Inflammatory Agents, Non-SteroidalAntirheumatic AgentsColchicineDouble-Blind MethodFemaleGoutHumansInterleukin 1 Receptor Antagonist ProteinMaleMiddle AgedRandomized Controlled Trials as TopicReproducibility of ResultsAnti-Inflammatory Agents, Non-SteroidalAntirheumatic AgentsColchicineInterleukin 1 Receptor Antagonist Proteingout attack intensityoutcome measurepainswellingtenderness

Identifiers

PMID30859221
PMCPMC6812713
OpenAlexW2922424183

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.