ArticleHepatology communications2019
Noninvasive Evaluation of Liver Fibrosis and Portal Hypertension After Successful Portoenterostomy for Biliary Atresia.
Article in Hepatology communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Ductular Reaction Underlies Development of Portal Hypertension in Biliary Atresia.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Association between post-Kasai cholangitis episodes, ursodeoxycholic acid regimen, and portal hypertension risk in biliary atresia: a multicenter cross-sectional study.Pediatric surgery international · 2026Article
- Serum aspartate aminotransferase to platelet ratio index in relation to liver histopathology of biliary atresia.Journal of pediatric gastroenterology and nutrition · 2026Observational
- Follow-up of jaundice-free biliary atresia survivors using M2BPGi and APRI in a local hospital.World journal of pediatric surgery · 2026Article
- Analysis of aspartate aminotransferase-to-platelet ratio index and liver fibrosis in biliary atresia.Journal of the colleges of medicine of South Africa · 2026Article
- The value of MMP-7 combined with serological markers in diagnosing liver fibrosis in children with biliary atresia.BMC pediatrics · 2025Article
- Serum bile acids early after portoenterostomy are predictive for native liver survival and portal hypertension in biliary atresia.Journal of pediatric gastroenterology and nutrition · 2025Observational
- Fibrotic liver injury in biliary atresia: long-term implications.World journal of pediatric surgery · 2025Review
- Portal vein hypoplasia is present in patients with biliary atresia at the time of diagnosis.Journal of pediatric gastroenterology and nutrition · 2024Observational
- Eicosapentaenoic acid administration ameliorates the progression of liver fibrosis after laparoscopic Kasai portoenterostomy.Pediatric surgery international · 2024Article
- Biliary atresia.Nature reviews. Disease primers · 2024Review
- Combi-Elasto Evaluation of the Degree of Liver Fibrosis in Children with Cholestatic Liver Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Liver fibrosis in children: a comprehensive review of mechanisms, diagnosis, and therapy.Clinical and experimental pediatrics · 2023Article
- Biliary Atresia in Adolescence and Adult Life: Medical, Surgical and Psychological Aspects.Journal of clinical medicine · 2023Review
- Liver secretin receptor predicts portoenterostomy outcomes and liver injury in biliary atresia.Scientific reports · 2022Article
- Diagnosis of liver cirrhosis with two-dimensional shear wave elastography in biliary atresia before Kasai portoenterostomy.Pediatric surgery international · 2022Article
- Life long follow up and management strategies of patients living with native livers after Kasai portoenterostomy.Scientific reports · 2021Article
- 60 Days in Biliary Atresia: A Historical Dogma Challenged.Clinical liver disease · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated noninvasive follow-up markers for histologic liver fibrosis and portal hypertension (PH) in patients with biliary atresia after successful portoenterostomy (PE). Among children with bilirubin <20 µmol/L after PE (n = 39), Metavir fibrosis stage was evaluated at PE and in follow-up protocol liver biopsies (n = 83). PH was defined as endoscopically confirmed esophageal varices or thrombocytopenia associated with splenomegaly. The accuracy of liver biochemistry and stiffness in detecting liver fibrosis and PH was analyzed by the area under the receiving operating characteristic curve (AUROC) and multiple regression models. During a median native liver survival of 8.3 years (interquartile range 2.5-10.8 years), cirrhosis (Metavir F4) had developed in 51% of patients and PH in 54% of patients. Cirrhosis was equally common in all age tertiles of 1.2-2.1 years (n = 10/27), 3.9-5.8 years (n = 12/28), and 9.0-14 years (n = 12/28). In the two oldest age tertiles, histologic liver fibrosis had progressed further in patients with PH than without PH (
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Registered trials
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