ReviewAlzheimer's & dementia (Amsterdam, Netherlands)2019
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.
Registry-linked trialOpen access · goldAbstract readReview
In one paragraph
Review in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06507488 (Daphnetin Capsule In the Treatment of VaScular COgnitive Impairment Without Dementia - A Randomized, Double-blind, Placebo-controlled Study), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Daphnetin Capsule In the Treatment of VaScular COgnitive Impairment Without Dementia - A Randomized, Double-blind, Placebo-controlled Study
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Pooled it
- Quantitative Relationship Between White Matter Hyperintensity Volume and Fazekas Score on Brain MRI.Stroke · 2026Article
- Accelerating Research on Brain Aging: Enabling Brain Imaging Data Sharing in the Open Science Landscape.European journal of neurology · 2026Review
- DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation.medRxiv : the preprint server for health sciences · 2025Article
- Association Between Platelet and Cerebral Small Vessel Disease: A Secondary Analysis Based on a Retrospective Cross-Sectional Study in Korean Adults.Brain and behavior · 2025Article
- Deep Medullary Vein Integrity and Relationships with Small Vessel Disease and Interstitial Diffusivity Measures in Patients with a Recent Small Subcortical Infarct.AJNR. American journal of neuroradiology · 2025Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- Perivascular and parenchymal brain fluid diffusivity in patients with a recent small subcortical infarct.Neuroradiology · 2025Article
- Extended Technical and Clinical Validation of Deep Learning-Based Brainstem Segmentation for Application in Neurodegenerative Diseases.Human brain mapping · 2025Article
- Sensitivity of diffusion tensor imaging to regional mixed cerebrovascular pathology.Brain communications · 2025Article
- Technical and clinical validation of a novel deep learning-based white matter hyperintensity segmentation tool.Cerebral circulation - cognition and behavior · 2025Article
- An evaluation of image-based and statistical techniques for harmonizing brain volume measurements.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cerebral small vessel disease lesion segmentation methods: A systematic review.Cerebral circulation - cognition and behavior · 2025Review
- Biological validation of peak-width of skeletonized mean diffusivity as a VCID biomarker: The MarkVCID Consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Clinical Relevance of Different Loads of Perivascular Spaces According to Their Localization in Patients with a Recent Small Subcortical Infarct.Journal of cardiovascular development and disease · 2024Article
- Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study.Alzheimer's research & therapy · 2024Observational
- Assessment of Small Vessel Function Using 7T MRI in Patients With Sporadic Cerebral Small Vessel Disease: The ZOOM@SVDs Study.Neurology · 2024Observational
- Functional and structural brain connectivity: Are they reproducible in cerebral small vessel disease?Cerebral circulation - cognition and behavior · 2024Article
- National and international collaborations to advance research into vascular contributions to cognitive decline.Cerebral circulation - cognition and behavior · 2024Article
- What have clinical trials taught us about brain health?Cerebral circulation - cognition and behavior · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors at 20 institutions in 12 countries.
Eric E SmithDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Geert Jan BiesselsDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands.
François De GuioDepartment of Neurology, Lariboisière Hospital, University Paris Diderot, Paris, France.
Frank Erik de LeeuwDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.
Simon DuchesneCERVO Research Center, Quebec Mental Health Institute, Québec, Canada.
Marco DüringInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU, Munich, Germany.
Richard FrayneDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.
Eric JouventDepartment of Neurology, Lariboisière Hospital, University Paris Diderot, Paris, France.
Bradley J MacIntoshHeart and Stroke Foundation Canadian Partnership for Stroke Recovery, Department of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Ontario, Canada.
Michael J ThrippletonCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Meike W VernooijDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.
Hieab AdamsDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.
Walter H BackesDepartment of Radiology & Nuclear Medicine, School for Mental Health & Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.
Lucia BalleriniCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Sandra E BlackHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.
Christopher ChenMemory Aging and Cognition Centre, Department of Pharmacology, National University of Singapore, Singapore.
Rod CorriveauNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Charles DeCarliDepartment of Neurology and Center for Neuroscience, University of California at Davis, Davis, CA, USA.
Steven M GreenbergJ. Philip Kistler Stroke Research Center, Stroke Service and Memory Disorders Unit, Massachusetts General Hospital, Boston, MA, USA.
M Edip GurolJ. Philip Kistler Stroke Research Center, Stroke Service and Memory Disorders Unit, Massachusetts General Hospital, Boston, MA, USA.
Michael IngrischDepartment of Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany.
Dominic JobCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Bonnie Y K LamTherese Pei Fong Chow Research Centre for Prevention of Dementia, Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Lenore J LaunerNational Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Jennifer LinnInstitute of Neuroradiology, University Hospital Carl Gustav Carus, Dresden, Germany.
Cheryl R McCrearyDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Vincent C T MokTherese Pei Fong Chow Research Centre for Prevention of Dementia, Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Leonardo PantoniLuigi Sacco Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
G Bruce PikeDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Joel RamirezHeart and Stroke Foundation Canadian Partnership for Stroke Recovery, Department of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Ontario, Canada.
Yael D ReijmerDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands.
Jose Rafael RomeroDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Stefan RopeleDepartment of Neurology, Medical University of Graz, Graz, Austria.
Natalia S RostJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, USA.
Perminder S SachdevCentre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia.
Christopher J M ScottHeart and Stroke Foundation Canadian Partnership for Stroke Recovery, Department of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Ontario, Canada.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
Mukul SharmaPopulation Health Research Institute, Hamilton, Ontario, Canada.
Steven SourbronImaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK.
Rebecca M E SteketeeDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Richard H SwartzDepartment of Medicine (Neurology), University of Toronto, Toronto, Canada.
Robert van OostenbruggeDepartment of Neurology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands.
Matthias van OschC.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Sanneke van RoodenDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Anand ViswanathanJ. Philip Kistler Stroke Research Center, Stroke Service and Memory Disorders Unit, Massachusetts General Hospital, Boston, MA, USA.
David WerringUniversity College London Queen Square institute of Neurology, London, UK.
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-Universität LMU, Munich, Germany.
Joanna M WardlawCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Sunnybrook Health Science Centre · CAErasmus MC · NLMassachusetts General Hospital · USUK Dementia Research Institute · GBUniversity of Calgary · CAChinese University of Hong Kong · HKGerman Center for Neurodegenerative Diseases · DELeiden University Medical Center · NLMaastricht University · NLUniversité Paris Cité · FRUniversity Medical Center Utrecht · NLBoston University · USInstitut Universitaire en Santé Mentale de Québec · CALudwig-Maximilians-Universität München · DEMedical University of Graz · ATNational Hospital for Neurology and Neurosurgery · GBNational Institute of Neurological Disorders and Stroke · USNational Institutes of Health · USNational University of Singapore · SGPopulation Health Research Institute · CA
Funding
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MEPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MCognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)RF1AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2018 to 2018
$6.1MPreclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young AdultsR01AG049607 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2015 to 2019
$3.1MMicroglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE ConsortiumUH3NS100605 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2018 to 2020
$3.0MCHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control SampleU01AG049505 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2014 to 2017
$3.0MADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model SystemsU01AG052409 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2016 to 2020
$1.6MMedical Research Council MR/J006971/1NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG054076NIA NIH HHS RF1 AG059421NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NINDS NIH HHS R01 NS017950NINDS NIH HHS UH3 NS100605
Abstract
introductionMany consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.
methodsSurveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.
resultsA framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.
conclusionsThe HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.
Indexed as
Cerebrovascular diseaseDementiaMagnetic resonance imagingRadiologyStroke
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT06507488ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.