Evidence map›Paper›PMID 30859101›Full record

ReviewFrontiers in cell and developmental biology2019

Thy-1 in Integrin Mediated Mechanotransduction.

Ping Hu, Thomas H Barker

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Crosstalk between mechanotransduction and metabolism.Nature reviews. Molecular cell biology · 2021
    Review
  12. Article
  13. Article
  14. Fibrosis in dysthyroid eye disease.Eye (London, England) · 2020
    Article
  15. Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold.Frontiers in cell and developmental biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ping HuDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.
Thomas H BarkerDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.

Funding

Mechanosensors that detect and treat Lung FibrosisR01HL132585 · NHLBI · UNIVERSITY OF VIRGINIA · PI BARKER, THOMAS HARRISON · 2015 to 2019
$3.3M
Targeting the alpha v integrin mechanotransduction axis in IPFR01HL127283 · NHLBI · UNIVERSITY OF VIRGINIA · PI BARKER, THOMAS HARRISON · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL127283NHLBI NIH HHS R01 HL132585
6 · The paper itself

Abstract

The glycosylphosphatidylinositol (GPI) anchored glycoprotein Thy-1 has been prevalently expressed on the surface of various cell types. The biological function of Thy-1 ranges from T cell activation, cell adhesion, neurite growth, differentiation, metastasis and fibrogenesis and has been extensively reviewed elsewhere. However, current discoveries implicate Thy-1 also functions as a key mechanotransduction mediator. In this review, we will be focusing on the role of Thy-1 in translating extracellular mechanic cues into intracellular biological cascades. The mechanotransduction capability of Thy-1 relies on

Indexed as

cis interactionintegrinmechanotransductionThy-1trans interaction

Identifiers

PMID30859101
PMCPMC6397864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.