ArticleJournal of reproduction & infertility
Comparing the Impact of Autologous Platelet-rich Plasma and Granulocyte Colony Stimulating Factor on Pregnancy Outcome in Patients with Repeated Implantation Failure.
Article in Journal of reproduction & infertility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03945812 (The Impact of Using Platelet-Rich Plasma Versus Granulocyte Colony-Stimulating Factor Versus Placebo on the Outcomes of Frozen Embryo Transfer), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Using Platelet-Rich Plasma Versus Granulocyte Colony-Stimulating Factor Versus Placebo on the Outcomes of Frozen Embryo Transfer: A Double Blind Randomized Controlled Trial
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Autologous platelet-rich plasma for assisted reproduction.The Cochrane database of systematic reviews · 2024Pooled it
- The efficacy of intrauterine infusion of platelet rich plasma in women undergoing assisted reproduction: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Granulocyte-colony stimulating factor administration for subfertile women undergoing assisted reproduction.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of Autologous Platelet-Rich Plasma in women with repeated implantation failure undergoing assisted reproduction.JBRA assisted reproduction · 2022Trial
- Platelet-rich plasma versus granulocyte colony-stimulating factor in addressing recurrent implantation failure: A randomized, double-blind clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026Article
- Review
- Is it justified to offer intrauterine infusion of autologous PRP in women with repeated implantation failure?Human reproduction (Oxford, England) · 2025Review
- Embryo versus endometrial receptivity: untangling a complex debate.Frontiers in endocrinology · 2025Article
- Efficacy of intrauterine autologous blood cell derivatives in enhancing endometrial thickness and IVF outcomes for women with recurrent implantation failure: a retrospective cohort study.Journal of assisted reproduction and genetics · 2024Article
- The Efficiency of Introducing Intrauterine Infusion of Autologous Platelet-Rich Plasma versus Granulocyte Colony-Stimulating Factor in Repeated Implantation Failure Patients: An Unblinded Randomised Clinical Trial.International journal of fertility & sterility · 2024Article
- Effectiveness of Autologous Platelet-Rich Plasma Therapy in Women with Repeated Implantation Failure: A Randomized Clinical Trial.International journal of fertility & sterility · 2024Article
- Clinical Application of Platelet Concentrates in Bovine Practice: A Systematic Review.Veterinary sciences · 2023Review
- Platelet-Rich Plasma Intrauterine Infusion as Assisted Reproduction Technology (ART) to Combat Repeated Implantation Failure (RIF): A Systematic Review and Meta-Analysis.Iranian journal of public health · 2023Review
- Efficacy of Autologous Intrauterine Infusion of Platelet-Rich Plasma in Patients with Unexplained Repeated Implantation Failures in Embryo Transfer: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Is There any Role for Granulocyte Colony Stimulating Factor in Improvement of Implantation in Intrauterine Insemination? A Prospective Double-Blind Randomized Control Trial.International journal of fertility & sterility · 2022Article
- The effect of platelet-rich plasma on the improvement of pregnancy results in repeated implantation failure: A randomized controlled trial.International journal of reproductive biomedicine · 2022Article
- Article
- Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- A narrative review of platelet-rich plasma (PRP) in reproductive medicine.Journal of assisted reproduction and genetics · 2021Review
- Platelet-Rich Plasma as a Potential New Strategy in the Endometrium Treatment in Assisted Reproductive Technology.Frontiers in endocrinology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the advancements in assisted reproductive technologies, repeated implantation failure (RIF) still remains a challenging problem for patients and clinicians. The aim of the present study was to compare the impact of intrauterine infusion of autologous platelet-rich plasma (PRP) and systemic administration of granulocyte colony stimulating factor (GCSF) on pregnancy outcome in patients with repeated implantation failure.
methodsThe present retrospective cohort study included 123 patients with history of more than two repeated failed embryo transfers. Cycles were divided into two groups of intrauterine infusion of PRP (n=67) and systemic administration of GCSF (n=56). Pregnancy outcome was compared between two groups. The p-value less than 0.05 was considered statistically significant.
resultsThe clinical pregnancy rate was significantly higher in PRP group than GCSF group (40.3% versus 21.4%, p=0.025). The crud and adjusted odds ratios (95% confidence interval (CI)) were 2.5 and 2.6 (p=0.025, CI: 1.11-5.53 and p=0.03, CI: 1.10-6.15), respectively.
conclusionIt seems that intrauterine infusion of PRP can positively affect pregnancy outcome in RIF patients in comparison with systemic administration of GCSF and more studies need to be designed to conclude the effectiveness of this method.
Indexed as
Identifiers
30859080PMC6386791What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.