ArticlePlastic and reconstructive surgery. Global open2019
Comparing Negative Pressure Wound Therapy with Instillation and Conventional Dressings for Sternal Wound Reconstructions.
Article in Plastic and reconstructive surgery. Global open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Effects of negative pressure wound therapy with instillation and dwell time (NPWTi-d) versus NPWT or standard of care in orthoplastic surgery: A systematic review and meta-analysis.International wound journal · 2023Pooled it
- Clinical application and efficacy of negative pressure wound therapy with instillation and dwell time (NPWTi-d): A systematic review and meta-analysis.International wound journal · 2020Pooled it
- Effectiveness of Negative Pressure Wound Therapy With Instillation and Dwell in Removing Nonviable Tissue, Promoting Granulation Tissue, and Reducing Surgical Debridements: A Systematic Literature Review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
- The impact of negative-pressure wound therapy with instillation on wounds requiring operative debridement: Pilot randomised, controlled trial.International wound journal · 2020Trial
- Economic Impact of Negative Pressure Wound Therapy With Instillation Compared With Standard Negative Pressure Wound Therapy and Gauze Dressing in Acute Traumatic Wounds.International wound journal · 2026Article
- Managing Drainless Mastectomy With Closed Incision Negative Pressure Wound Therapy Using Full-coverage Foam Dressings.Plastic and reconstructive surgery. Global open · 2025Article
- Negative Pressure Wound Therapy With Instillation and Closed Incision Negative Pressure Therapy Use in South Africa: Expert Panel Recommendations.International wound journal · 2025Article
- Clinical impact of closed-incision negative-pressure therapy in DIEP flap breast reconstruction's donor site.Updates in surgery · 2025Article
- A Comparative Analysis of Negative Pressure Wound Therapy Methods for Sternal Wound Infections.Plastic and reconstructive surgery. Global open · 2025Article
- Finite element and preclinical analysis of tissue response to negative pressure wound therapy with a felted foam containing 10 mm through holes.Frontiers in bioengineering and biotechnology · 2025Article
- Negative Pressure Wound Therapy with Instillation and Dwell Time Using Antiseptic Solution in Chronic Limb-threatening Ischemia.Plastic and reconstructive surgery. Global open · 2024Article
- The role of negative pressure wound therapy with instillation and dwell time in the treatment of deep sternal wound infections-A retrospective cohort study.Health science reports · 2023Article
- Applied Usage and Tips of High Stretch Fixation NPWTi-d for Sternal Osteomyelitis.Plastic and reconstructive surgery. Global open · 2023Article
- Negative Pressure Wound Therapy With Instillation and Dwell Time: Mechanisms of Action Literature Review.Eplasty · 2023Review
- Use of a Modified ABTHERA ADVANCE™ Open Abdomen Dressing with Intrathoracic Negative-Pressure Therapy for Temporary Chest Closure After Damage Control Thoracotomy.The American journal of case reports · 2022Review
- The use of closed incision negative pressure therapy for incision and surrounding soft tissue management: Expert panel consensus recommendations.International wound journal · 2022Review
- Closed incision negative pressure therapy following abdominoplasty after breast reconstruction with deep inferior epigastric perforator flaps.International wound journal · 2020Article
- Negative pressure wound therapy with instillation: International consensus guidelines update.International wound journal · 2020Article
- Clinical efficacy of intermittent magnetic pressure therapy for ear keloid treatment after excision.Archives of craniofacial surgery · 2019Article
- Closed Incision Negative Pressure Therapy for the Recipient Site in Head and Neck Reconstruction.OTO openArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMuscle flap reconstruction has become a mainstay of therapy following treatment of sternal wound complications; however, success depends on removing wound exudate and infectious material from the wound before reconstruction and closure. Importantly, time to closure is a key factor affecting morbidity/mortality and cost-to-treat for this wound type.
methodsA retrospective analysis of 30 patients who were treated for sternal wound complications between June 2015 and October 2017 was performed. After surgical debridement, group 1 patients (n = 15) received negative pressure wound therapy (NPWT) with instillation and dwell time (NPWTi-d), instilling 1/8-strength Dakin's solution with a 20-minute dwell time followed by 2 hours of NPWT (-125 mm Hg); group 2 patients (n = 15) were treated with wet-to-moist dressings soaked in 1/8-strength Dakin's solution. After muscle flap reconstruction and closure with sutures, group 1 patients received closed incision negative pressure therapy, and group 2 patients received Benzoin and wound closure strips. Data collected included time to closure, therapy duration, number of debridements/dressing changes, drain duration, and complications.
resultsThere was a significantly shorter time to closure (
conclusionsWe describe a novel regimen consisting of adjunctive NPWTi-d, along with debridement and systemic antibiotics, followed by closed incision negative pressure therapy after muscle flap reconstruction and closure, to help manage preexisting sternal wounds that had failed to close following a previous cardiac procedure.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.