Evidence map›Paper›PMID 30859005›Full record

ArticleNeurology. Clinical practice2019

Quality of life outcomes in patients presenting for evaluation of CNS tumors.

Alexander Chaitoff, Nehaw Sarmey, Nicolas R Thompson, Youran Fan, Manmeet Ahluwalia, Irene L Katzan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alexander ChaitoffCleveland Clinic Lerner College of Medicine of Case Western Reserve University (A.C., M.A., I.L.K.); Department of Neurosurgery (N.S.), Cleveland Clinic; Neurological Institute Center for Outcomes Research & Evaluation (N.R.T., Y.F., I.L.K.), Cleveland Clinic; Department of Quantitative Health Sciences (N.R.T., Y.F.), Cleveland Clinic; and Neurological Institute Brain Tumor and Neuro-Oncology Center (M.A.), Cleveland Clinic, OH.
Nehaw SarmeyCleveland Clinic Lerner College of Medicine of Case Western Reserve University (A.C., M.A., I.L.K.); Department of Neurosurgery (N.S.), Cleveland Clinic; Neurological Institute Center for Outcomes Research & Evaluation (N.R.T., Y.F., I.L.K.), Cleveland Clinic; Department of Quantitative Health Sciences (N.R.T., Y.F.), Cleveland Clinic; and Neurological Institute Brain Tumor and Neuro-Oncology Center (M.A.), Cleveland Clinic, OH.
Nicolas R ThompsonCleveland Clinic Lerner College of Medicine of Case Western Reserve University (A.C., M.A., I.L.K.); Department of Neurosurgery (N.S.), Cleveland Clinic; Neurological Institute Center for Outcomes Research & Evaluation (N.R.T., Y.F., I.L.K.), Cleveland Clinic; Department of Quantitative Health Sciences (N.R.T., Y.F.), Cleveland Clinic; and Neurological Institute Brain Tumor and Neuro-Oncology Center (M.A.), Cleveland Clinic, OH.
Youran FanCleveland Clinic Lerner College of Medicine of Case Western Reserve University (A.C., M.A., I.L.K.); Department of Neurosurgery (N.S.), Cleveland Clinic; Neurological Institute Center for Outcomes Research & Evaluation (N.R.T., Y.F., I.L.K.), Cleveland Clinic; Department of Quantitative Health Sciences (N.R.T., Y.F.), Cleveland Clinic; and Neurological Institute Brain Tumor and Neuro-Oncology Center (M.A.), Cleveland Clinic, OH.
Manmeet AhluwaliaCleveland Clinic Lerner College of Medicine of Case Western Reserve University (A.C., M.A., I.L.K.); Department of Neurosurgery (N.S.), Cleveland Clinic; Neurological Institute Center for Outcomes Research & Evaluation (N.R.T., Y.F., I.L.K.), Cleveland Clinic; Department of Quantitative Health Sciences (N.R.T., Y.F.), Cleveland Clinic; and Neurological Institute Brain Tumor and Neuro-Oncology Center (M.A.), Cleveland Clinic, OH.
Irene L KatzanCleveland Clinic Lerner College of Medicine of Case Western Reserve University (A.C., M.A., I.L.K.); Department of Neurosurgery (N.S.), Cleveland Clinic; Neurological Institute Center for Outcomes Research & Evaluation (N.R.T., Y.F., I.L.K.), Cleveland Clinic; Department of Quantitative Health Sciences (N.R.T., Y.F.), Cleveland Clinic; and Neurological Institute Brain Tumor and Neuro-Oncology Center (M.A.), Cleveland Clinic, OH.
Cleveland Clinic · USCase Western Reserve University · USCleveland Clinic Lerner College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe describe patient-reported outcomes (PROs) in adults with CNS tumors and evaluate their correlation with physician-reported functional status.

methodsWe completed a retrospective cohort study of patients managed at a high-volume CNS tumor institute between September 2013 and September 2014. PROs were measured using 6 domains from the PROs Measurement Information System (PROMIS): anxiety, physical function, pain interference, sleep disturbance, fatigue, and satisfaction with social roles. Physician-reported outcomes were measured using the Eastern Cooperative Oncology Group Scale of Performance Status (ECOG). We compared differences in PROMIS scores across tumor types using analysis of variance and measured the correlation between PROMIS scores and ECOG scores using spearman correlations. Finally, we compared the range of PROMIS physical function scores within each ECOG level.

resultsIn a cohort of 2,828 patients, 1,284 (45.4%) completed all 6 PROMIS domains. There were significant differences in PROMIS scores across tumor types for all domains except anxiety. The strength of the correlation between PROMIS and ECOG scores was weak to moderate for all PROMIS domains (all

conclusionsSymptom burden was associated with tumor type. There were only weak to moderate correlations between PROMIS and ECOG scores, underscoring the importance of integrating PROs into clinical practice for patients with CNS tumors.

Identifiers

PMID30859005
PMCPMC6382371
OpenAlexW2902610318

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.