Evidence map›Paper›PMID 30858965›Full record

ArticleJournal of tissue engineering

A parameterised mathematical model to elucidate osteoblast cell growth in a phosphate-glass microcarrier culture.

Iva Burova, Carlotta Peticone, David De Silva Thompson, Jonathan C Knowles, Ivan Wall, Rebecca J Shipley

Abstract read
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iva BurovaDepartment of Mechanical Engineering, University College London, London, UK.ORCID https://orcid.org/0000-0003-3936-8673
Carlotta PeticoneDepartment of Biochemical Engineering, University College London, London, UK.
David De Silva ThompsonDepartment of Biochemical Engineering, University College London, London, UK.
Jonathan C KnowlesDivision of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, London, UK.
Ivan WallDepartment of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of Korea.ORCID https://orcid.org/0000-0001-6294-8348
Rebecca J ShipleyDepartment of Mechanical Engineering, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue engineering has the potential to augment bone grafting. Employing microcarriers as cell-expansion vehicles is a promising bottom-up bone tissue engineering strategy. Here we propose a collaborative approach between experimental work and mathematical modelling to develop protocols for growing microcarrier-based engineered constructs of clinically relevant size. Experiments in 96-well plates characterise cell growth with the model human cell line MG-63 using four phosphate glass microcarrier materials. Three of the materials are doped with 5 mol% TiO

Indexed as

biomaterialsbioprocessingcell culturecobaltmathematical modellingmicrocarriersphosphate glassTissue engineeringtitanium

Identifiers

PMID30858965
PMCPMC6402060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.