ArticleHereditary cancer in clinical practice2019
Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report.
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Article in Hereditary cancer in clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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36citing papers in PubMed, 3 pooled it
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36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer.International journal of clinical oncology · 2026Guideline
- Gynaecological cancer surveillance for women with Lynch syndrome: systematic review and cost-effectiveness evaluation.Health technology assessment (Winchester, England) · 2024Pooled it
- Testing strategies for Lynch syndrome in people with endometrial cancer: systematic reviews and economic evaluation.Health technology assessment (Winchester, England) · 2021Pooled it
- Trial
- Clinical utility of diagnosing Lynch syndrome in gynecologic oncology: a joint statement from four Japanese academic societies.International journal of clinical oncology · 2026Review
- Routes to colorectal cancer in Lynch syndrome: a decade of molecular and clinical insights converging on Schrödinger's cat.Familial cancer · 2026Review
- Transitioning from the Prospective Lynch Syndrome Database (PLSD) to the International Lynch Syndrome Database (ILSD).Familial cancer · 2026Article
- Lynch Syndrome as a Spectrum of Four Distinct Genetic Disorders: Toward Genotype-Guided Precision Management in the NGS Era.Cancers · 2026Review
- Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences.Hereditary cancer in clinical practice · 2025Review
- Risk of metachronous colorectal cancer after surgical resection of index rectal cancer in Lynch syndrome: a multicenter retrospective study in Japan.Surgery today · 2024Article
- Colorectal cancer and advanced adenoma characteristics according to causative mismatch repair gene variant in Japanese colorectal surveillance for Lynch syndrome.Journal of gastroenterology · 2024Article
- Detection of (pre)cancerous colorectal lesions in Lynch syndrome patients by microsatellite instability liquid biopsy.Cancer gene therapy · 2024Article
- Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated "Big Bang" pathway to CRC in three of the four Lynch syndromes.Hereditary cancer in clinical practice · 2024Article
- Dominantly inherited micro-satellite instable cancer - the four Lynch syndromes - an EHTG, PLSD position statement.Hereditary cancer in clinical practice · 2023Review
- The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review.Cancers · 2023Review
- The "scope" of colorectal cancer screening in Lynch syndrome: is there an optimal interval?Journal of the National Cancer Institute · 2023Article
- Review
- Lynch syndrome: from detection to treatment.Frontiers in oncology · 2023Review
- Review
- Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium.Hereditary cancer in clinical practice · 2022Article
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Authors and funding
57 authors at 20 institutions in 14 countries.
Toni T Seppälä1Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS Helsinki, Finland.ORCID 0000-0002-4940-3498
Aysel Ahadova3Heidelberg University Hospital and DKFZ, Heidelberg, Germany.
Mev Dominguez-Valentin4Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.
Finlay Macrae6The Royal Melbourne Hospital, Melbourne, Australia.
D Gareth Evans8University of Manchester & Manchester University Hospitals Foundation Trust, Manchester, UK.
Christina TherkildsenThe Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark.
Julian Sampson10Medical Genetics, Cardiff University, Cardiff, UK.
Rodney ScottUniversity of Newcastle and the Hunter Medical Research Institute, Callaghan, Australia.
John Burn12University of Newcastle, Newcastle upon Tyne, UK.
Gabriela Möslein13University Witten-Herdecke, Wuppertal, Germany.
Inge Bernstein14Dept. of Surgical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark.
Elke Holinski-Feder15Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany.
Kirsi Pylvänäinen17Central Finland Central Hospital, Education and Research, Jyväskylä, Finland.
Laura Renkonen-Sinisalo1Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS Helsinki, Finland.
Anna Lepistö1Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS Helsinki, Finland.
Charlotte Kvist Lautrup18Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark.
Annika Lindblom19Karolinska Institutet, Stockholm, Sweden.
John-Paul Plazzer6The Royal Melbourne Hospital, Melbourne, Australia.
Ingrid Winship6The Royal Melbourne Hospital, Melbourne, Australia.
Douglas Tjandra6The Royal Melbourne Hospital, Melbourne, Australia.
Lior H Katz20Hadassah Medical Center, Jerusalem, and Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel.
Stefan Aretz21Institute of Human Genetics, University of Bonn, Bonn, Germany.
Robert Hüneburg22Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
Stefanie Holzapfel22Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
Karl Heinimann24Institute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Adriana Della ValleHospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay.
Florencia NeffaHospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay.
Nathan GluckTel-Aviv Soursky Medical Center, Tel-Aviv, Israel.
Wouter H de Vos Tot Nederveen Cappel27Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands.
Hans Vasen28Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
Monika Morak15Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany.
Verena Steinke-Lange15Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany.
Christoph Engel29Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Nils Rahner30Medical School, Institute of Human Genetics, Heinrich-Heine-University, Düsseldorf, Germany.
Wolff Schmiegel31Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
Deepak Vangala31Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany.
Huw Thomas32St Mark's Hospital, Department of Surgery and Cancer, Imperial College London, London, UK.
Kate Green8University of Manchester & Manchester University Hospitals Foundation Trust, Manchester, UK.
Fiona Lalloo8University of Manchester & Manchester University Hospitals Foundation Trust, Manchester, UK.
Emma J Crosbie33University of Manchester and St Mary's Hospital, Manchester, UK.
James Hill8University of Manchester & Manchester University Hospitals Foundation Trust, Manchester, UK.
Gabriel CapellaHereditary Cancer Program, Catalan Institute of Oncology, Insititut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, L'Hospitalet de Llobregat, Barcelona, Spain.
Marta PinedaHereditary Cancer Program, Catalan Institute of Oncology, Insititut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, L'Hospitalet de Llobregat, Barcelona, Spain.
Matilde NavarroHereditary Cancer Program, Catalan Institute of Oncology, Insititut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, L'Hospitalet de Llobregat, Barcelona, Spain.
Ignacio BlancoHereditary Cancer Program, Catalan Institute of Oncology, Insititut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, L'Hospitalet de Llobregat, Barcelona, Spain.
Sanne Ten Broeke36University Medical Center Groningen, Groningen, the Netherlands.
Maartje Nielsen37Leids Universitair Medisch Centrum, Leiden, Netherlands.
Ken Ljungmann38Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Sigve Nakken4Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.
Noralane Lindor39Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ USA.
Ian Frayling10Medical Genetics, Cardiff University, Cardiff, UK.
Eivind Hovig4Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.
Lone Sunde41Department of Medical Genetics, Aarhus University Hospital, Aarhus, Denmark.
Matthias Kloor3Heidelberg University Hospital and DKFZ, Heidelberg, Germany.
Jukka-Pekka Mecklin42Department of Surgery, Central Finland Central Hospital, Jyväskylä, Finland.
Mette Kalager4Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.
Pål Møller4Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway.
University of Manchester · GBInstitut d'Investigació Biomédica de Bellvitge · ESThe Royal Melbourne Hospital · AULMU Klinikum · DEOslo University Hospital · NOAalborg University Hospital · DKAarhus University Hospital · DKCardiff University · GBCentral Finland Health Care District · FIHeidelberg University · DEHelsinki University Hospital · FIHospital Central de las Fuerzas Armadas · UYLeiden University · NLUniversitätsklinikum Knappschaftskrankenhaus Bochum · DEUniversity Hospital Bonn · DECopenhagen University Hospital · DKHeinrich Heine University Düsseldorf · DEHunter Medical Research Institute · AUIsala · NLKarolinska Institutet · SE
Funding
Department of Health NIHR-CS-012-009
Abstract
backgroundRecent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (
methodsTo inform the debate, we examined, in the Prospective Lynch Syndrome Database (PLSD), whether the time since last colonoscopy was associated with the pathological stage at which CRC was diagnosed during prospective surveillance.
resultsStage at diagnosis and interval between last prospective surveillance colonoscopy and diagnosis were available for 209 patients with 218 CRCs, including 162
conclusionsThe CRC stage and interval since last colonoscopy were not correlated, which is in conflict with the accelerated adenoma-carcinoma paradigm. We have previously reported that more frequent colonoscopy is not associated with lower incidence of CRC in
Indexed as
ColonoscopyColorectal cancerEndoscopyHereditary cancerHereditary nonpolyposis colorectal cancerLynch syndromeMicrosatellite instabilityMismatch repairOver-diagnosisScreeningSurveillance
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