ArticleNutrition & metabolism2019
Stingless bee honey protects against lipopolysaccharide induced-chronic subclinical systemic inflammation and oxidative stress by modulating Nrf2, NF-κB and p38 MAPK.
Article in Nutrition & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 108 citations in OpenAlex.
- Honey as a Natural Flavorful Product: A Comprehensive Review of Its Potential Biological Activities and Recent Studies.Food science & nutrition · 2026Review
- Screening of Phytotoxins in Raw Honey and the Honey Sugar Matrix's Modulatory Effects on Their Toxicity.Foods (Basel, Switzerland) · 2026Article
- Ergosterol alleviates lipopolysaccharide-induced acute kidney injury in rats via a mechanistic modulation of TLR4/p-p38/NF-κB, iNOS/NO and Nrf2/HO-1 signaling pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Alleviation of Aflatoxin B1-Induced Hepatic Damage by Propolis: Effects on Inflammation, Apoptosis, and Cytochrome P450 Enzyme Expression.Current issues in molecular biology · 2026Article
- Kelulut Honey-Incorporated Hybrid Gelatin-PVA Hydrogel for Wound Healing: Fabrication and In Vitro Characterization.Polymers · 2025Article
- Nutritional Composition, Volatile Profiles, and Biological Evaluation of Honeys fromPlants (Basel, Switzerland) · 2025Article
- Effects of a Stingless Bee Honey Mouth Rinse on Dental Plaque Accumulation: A Randomised Clinical Trial.Cureus · 2025Article
- Polycystic Ovary Syndrome and Oxidative Stress. Natural Treatments.Current medicinal chemistry · 2025Review
- Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model.Anatomy & cell biology · 2024Article
- Dandelion root extracts and taraxasterol inhibit LPS‑induced colorectal cancer cell viability by blocking TLR4‑NFκB‑driven ACE2 and TMPRSS2 pathways.Experimental and therapeutic medicine · 2024Article
- Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis.Antibiotics (Basel, Switzerland) · 2024Review
- Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS.Molecules (Basel, Switzerland) · 2023Article
- Understanding the prevalence, progression, and management of metabolic syndrome in Saudi Arabia.Saudi medical journal · 2023Review
- The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation.BMC complementary medicine and therapies · 2023Article
- Review
- NF-κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective.Journal of cellular and molecular medicine · 2023Review
- Antioxidants Discovery for Differentiation of Monofloral Stingless Bee Honeys Using Ambient Mass Spectrometry and Metabolomics Approaches.Foods (Basel, Switzerland) · 2023Article
- The Potential Use of Honey as a Neuroprotective Agent for the Management of Neurodegenerative Diseases.Nutrients · 2023Review
- The Mechanism of Kelulut Honey in Reversing Metabolic Changes in Rats Fed with High-Carbohydrate High-Fat Diet.Molecules (Basel, Switzerland) · 2023Article
- Intra-socket application of medical-grade honey after tooth extraction attenuates inflammation and promotes healing in cats.Journal of feline medicine and surgery · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiological and experimental studies have extensively indicated that chronic subclinical systemic inflammation (CSSI) and oxidative stress are risk factors for several chronic diseases, including cancer, arthritis, type 2 diabetes, and cardiovascular and neurodegenerative diseases. This study examined the protective effect of stingless bee honey (SBH) supplementation against lipopolysaccharide (LPS)-induced CSSI, pointing to the possible involvement of NF-κB, p38 MAPK and Nrf2 signaling.
methodsCSSI was induced in male Sprague Dawley rats by intraperitoneal injection of LPS three times per week for 28 days, and SBH (4.6 and 9.3 g/kg/day) was supplemented for 30 days.
resultsLPS-induced rats showed significant leukocytosis, and elevated serum levels of CRP, TNF-α, IL-1β, IL-6, IL-8, MCP-1, malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), accompanied with diminished antioxidants. Treatment with SBH significantly ameliorated inflammatory markers, MDA and 8-OHdG, and enhanced antioxidants in LPS-induced rats. In addition, SBH decreased NF-κB p65 and p38 MAPK, and increased Nrf2 expression in the liver, kidney, heart and lung of LPS-induced rats. Furthermore, SBH prevented LPS-induced histological and functional alterations in the liver, kidney, heart and lung of rats.
conclusionSBH has a substantial protective role against LPS-induced CSSI in rats mediated via amelioration of inflammation, oxidative stress and NF-κB, p38 MAPK and Nrf2 signaling.
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Registered trials
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