ReviewFrontiers in endocrinology2019
Subclinical Hypothyroidism in Children: When a Replacement Hormonal Treatment Might Be Advisable.
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Bibliometric analysis of research on pediatric hypothyroidism treatment: a global perspective on trends and emerging fronts (2018-2026).Frontiers in pediatrics · 2026Pooled it
- A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Subclinical Hypothyroidism in Children: Natural History, Risk Factors, and OutcomesJournal of clinical research in pediatric endocrinology · 2026Article
- Subtle diastolic dysfunction in children with idiopathic subclinical hypothyroidism: effect of two years of l-thyroxine treatment.Journal of endocrinological investigation · 2026Article
- Factors associated with levothyroxine withdrawal and development of a prediction model in primary hypothyroidism.Frontiers in endocrinology · 2026Article
- Growth impairment in children with atrophic autoimmune thyroiditis and pituitary hyperplasia.Italian journal of pediatrics · 2024Article
- Characterization of Hashimoto´s thyroiditis in Sudanese children: a cross-sectional study at Gaafar Ibnauf Hospital, Khartoum.The Pan African medical journal · 2023Article
- Subclinical hypothyroidism in children and adolescents as mild dysfunction of the thyroid gland: a single-center study.Pediatric endocrinology, diabetes, and metabolism · 2023Article
- Potential Association between Subclinical Hypothyroidism and Childhood Migraine.Medicina (Kaunas, Lithuania) · 2022Article
- Thyroid abnormalities in children with Down syndrome at St. Paul's hospital millennium medical college, Ethiopia.Endocrinology, diabetes & metabolism · 2022Review
- Obesity is associated with subclinical hypothyroidism in the presence of thyroid autoantibodies: a cross-sectional study.BMC endocrine disorders · 2022Article
- Subclinical Hypothyroidism: Prevalence, Health Impact, and Treatment Landscape.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- Subclinical hypothyroidism in children: updates for pediatricians.Annals of pediatric endocrinology & metabolism · 2021Article
- Re: Thyroid Dysfunction in Children with Idiopathic Nephrotic Syndrome Attending a Paediatric Hospital in Qazvin, Iran.Sultan Qaboos University medical journal · 2021Article
- Unusual cause of congenital hypothyroidism in a term infant.BMJ case reports · 2021Article
- Subclinical Hypothyroidism as the Most Common Thyroid Dysfunction Status in Children With Down's Syndrome.Frontiers in endocrinology · 2021Article
- Thyroid Dysfunction in Children with Idiopathic Nephrotic Syndrome Attending a Paediatric Hospital in Qazvin, Iran.Sultan Qaboos University medical journal · 2020Article
- Subclinical hypothyroidism in childhood, treatment or only follow-up?BMC pediatrics · 2020Article
- Long-Term Follow-Up and Outcomes of Autoimmune Thyroiditis in Childhood.Frontiers in endocrinology · 2020Article
- Thyroid hormone therapy for subclinical hypothyroidism.Endocrine · 2019Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim of this mini review was to analyze the main variables which should be taken into account when the decision regarding a possible treatment with L-T4 has to be considered for a child with subclinical hypothyroidism (SH). The indications of periodical monitoring and vigilance have been also discussed. It was inferred that therapy should be recommended for children with underlying Hashimoto's thyroiditis and progressive deterioration of thyroid status over time, particularly in the cases with goiter and hypothyroid symptoms and in those with associated Turner syndrome or Down's syndrome and/or other autoimmune diseases. Treatment might also be recommended for children with proatherogenic metabolic abnormalities. Treatment is not advisable in children with idiopathic and mild SH, no goiter, no hypothyroid symptoms and negative anti-thyroid autoantibodies. In the absence of any therapeutic intervention, clinical status and thyroid function tests should be periodically monitored, in order to individuate the children who might benefit from treatment. It has been suggested that children with a persistent mild elevation of TSH, who are not treated with L-T4, should undergo biochemical monitoring of thyroid function and re-assessment of clinical status every 6 months. After 2 years with stable thyroid function tests, the interval between monitoring can be extended.
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