Evidence map›Paper›PMID 30858704›Full record

ArticleNeuropsychiatric disease and treatment2019

Radio electric asymmetric conveyer neuromodulation in depression, anxiety, and stress.

Arianna Rinaldi, Chiara Rinaldi, José Alfredo Coelho Pereira, Matteo Lotti Margotti, Marina Nolli Bittencourt, Ana Rita Pinheiro Barcessat, Vania Fontani, Salvatore Rinaldi

Registry-linked trialAbstract read
In one paragraph

Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07373366 (Effects of Neurobiological Therapy With Asymmetric Radio-electric Conveyer), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07373366 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Neurobiological Therapy With Asymmetric Radio-electric Conveyer (REAC) in Diffuse Axonal Injury: a Randomized Controlled Trial.

TypeinterventionalSponsorUniversity of Sao PauloRan2025 to 2027Enrolled60ConditionsTraumatic Brain InjuryArmsSubjects in the intervention group receive low-frequency radioelectric therapy, Sham, the device simulates a therapy session
3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arianna RinaldiDepartment of Neuro Psycho Physio Pathology and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy, srinaldi@irf.it.
Chiara RinaldiDepartment of Neuro Psycho Physio Pathology and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy, srinaldi@irf.it.
José Alfredo Coelho PereiraResearch Department, Rinaldi Fontani Foundation, Florence, Italy, srinaldi@irf.it.
Matteo Lotti MargottiDepartment of Neuro Psycho Physio Pathology and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy, srinaldi@irf.it.
Marina Nolli BittencourtGraduate Program in Health Sciences, Universidade Federal do Amapá, Amapá, Brazil.
Ana Rita Pinheiro BarcessatGraduate Program in Health Sciences, Universidade Federal do Amapá, Amapá, Brazil.
Vania FontaniDepartment of Neuro Psycho Physio Pathology and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy, srinaldi@irf.it.
Salvatore RinaldiDepartment of Neuro Psycho Physio Pathology and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence, Italy, srinaldi@irf.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was to assess the efficacy of specific neuromodulation treatments performed with radio electric asymmetric conveyer (REAC) technology in the treatment of the symptomatic triad depression, anxiety, and stress by the use of a specific psychometric test such as the Depression Anxiety Stress Scale-42 items (DASS-42) version, which assesses simultaneously the severity of expression of this triad. PATIENTS AND

methodsThe design of this study was planned to compare two populations that performed DASS-42 test twice within a similar period of time. The first population performed the first DASS test before the treatment and the second test about 3 months later, at the end of two specific REAC neuromodulation treatments, neuropostural optimization (NPO) and neuropsychophysical optimization (NPPO), that have previously shown an efficacy in the treatment of depression, anxiety and stress. The second population (untreated), used as the randomized control group, consisted of a similar group by gender and age, who performed the DASS-42 test in an online platform twice, with an interval of about 3 months between the first and second tests, similar to the interval between the two tests in the treated group.

resultsThe comparison between the treated group and the control group points out the REAC treatment efficacy in improving the quality of life. At the second DASS-42 test, self-administered about 3 months after the treatments, treated patients were positioned on average values of much milder severity in all the three clusters, depression, anxiety, and stress, while in untreated patients there was no significant difference between the mean values of the first and second DASS tests.

conclusionThe results obtained in this study, evaluated with the DASS-42 test, confirm that REAC-NPO and REAC-NPPO neuromodulation treatments can be useful tools for the clinical treatment of depression, anxiety, and stress, as already proven by previous results evaluated with different psychometric tests.

Indexed as

adaptive behaviorbehavior disordersmood disordersneurobiological modulationneurobiological stimulationpsychophysiological disordersREAC

Identifiers

PMID30858704
PMCPMC6387613

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.