ArticleClinical ophthalmology (Auckland, N.Z.)2019
Evaluation of limbal transplantation in eyes with bilateral severe ocular surface damage secondary to chemical injury.
Article in Clinical ophthalmology (Auckland, N.Z.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Outcomes of Limbal Stem Cell Transplant: A Meta-analysis.JAMA ophthalmology · 2020Pooled it
- Systematic Review of Bilateral Ocular Trauma: Considerations for Future Whole-eye Transplantation.Plastic and reconstructive surgery. Global open · 2026Article
- Outcomes of allogeneic ocular surface stem cell transplantation.Frontiers in ophthalmology · 2026Review
- Current Landscape and Future Prospects of Corneal Regenerative Medicine.Ophthalmology and therapy · 2026Review
- DNA damage in oral mucosal epithelial cells cultured in complex and xenobiotic-free media: a comparison study.Mutagenesis · 2025Article
- Limbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency.International ophthalmology · 2024Article
- The application of a 4D-printed chitosan-based stem cell carrier for the repair of corneal alkali burns.Stem cell research & therapy · 2024Article
- Focus on limbal stem cell deficiency and limbal cell transplantation.World journal of transplantation · 2023Review
- Chemical toxic exposures and chronic ocular pain.Frontiers in toxicology · 2023Review
- The Need for Improved Therapeutic Approaches to Protect the Cornea Against Chemotoxic Injuries.Translational vision science & technology · 2020Article
- Gene Delivery to Human Limbal Stem Cells Using Viral Vectors.Human gene therapy · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the outcome of limbal transplantation in eyes with bilateral severe ocular surface damage secondary to chemical injury. PATIENTS AND
methodsThis was a retrospective case series that included 20 patients who had undergone living related limbal transplantation due to the presence of bilateral severe stem cell deficiency resulting from chemical injury. Medical records of the selected patients were reviewed. The following data were recorded and analyzed: gender; age at the time of the surgery; duration of follow-up; corrected distance visual acuity (CDVA); symptoms; intraocular pressure (IOP); any complications; postoperative treatment; and other surgical procedures needed.
resultsThe mean age of the included patients was 27.4±9.3 years. The causative agent was an alkali in 14 patients. Fifteen patients (75%) had a stable ocular surface (ie, complete corneal re-epithelization and resolution of postoperative inflammation) after the first limbal transplantation, while the other five patients (25%) needed regrafting. As regards the IOP; five patients (25%) needed Ahmed's valve implantation to control the IOP. Other surgical procedures needed were penetrating keratoplasty (PKP) in three patients (15%), cataract surgery in six patients (30%), and lid surgery in one patient (5%).
conclusionIn conclusion, living related conjunctival limbal allograft transplantation, especially when combined with amniotic membrane transplantation, yielded good results in the management of cases with bilateral severe chemical eye injuries.
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