ArticleNature ecology & evolution2019
The genome of the jellyfish Clytia hemisphaerica and the evolution of the cnidarian life-cycle.
Article in Nature ecology & evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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90 citing papers in PubMed, 197 citations in OpenAlex.
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- Microbiome modulation in regeneration in jellyfish.PloS one · 2026Article
- Microrna Expression inMicroRNA (Shariqah, United Arab Emirates) · 2026Article
- The jellyfish Clytia hemisphaerica.Nature methods · 2026Article
- Sponges, ctenophores, and the statistical significance of syntenies.Molecular biology and evolution · 2025Article
- Investigating the evolution and features of regeneration using cnidarians.Integrative and comparative biology · 2025Review
- AnOpen biology · 2025Article
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- Genome assembly of Bougainvillia cf. muscus (Cnidaria: Hydrozoa).G3 (Bethesda, Md.) · 2025Article
- Aboral cell types ofScience advances · 2025Article
- Phylogenetic and structural analysis of Hydra ADAR.Archives of biochemistry and biophysics · 2025Article
- Genomes of the Caribbean reef-building corals Colpophyllia natans, Dendrogyra cylindrus, and Siderastrea siderea.G3 (Bethesda, Md.) · 2025Article
- Signaling Mechanism of Budding, Proliferation, and Tissue Regeneration in Cnidaria.Current issues in molecular biology · 2025Review
- A whole-body atlas of BMP signaling activity in an adult sea anemone.BMC biology · 2025Article
- Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari.BMC genomics · 2025Article
- Multiple developmental pathways in organisms with developmentally complex life cycles.Frontiers in cell and developmental biology · 2025Review
- Regulation of Green Fluorescent Proteins by Sea Anemones (Anthopleura spp.) in Response to Light.Integrative and comparative biology · 2024Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Jellyfish (medusae) are a distinctive life-cycle stage of medusozoan cnidarians. They are major marine predators, with integrated neurosensory, muscular and organ systems. The genetic foundations of this complex form are largely unknown. We report the draft genome of the hydrozoan jellyfish Clytia hemisphaerica and use multiple transcriptomes to determine gene use across life-cycle stages. Medusa, planula larva and polyp are each characterized by distinct transcriptome signatures reflecting abrupt life-cycle transitions and all deploy a mixture of phylogenetically old and new genes. Medusa-specific transcription factors, including many with bilaterian orthologues, associate with diverse neurosensory structures. Compared to Clytia, the polyp-only hydrozoan Hydra has lost many of the medusa-expressed transcription factors, despite similar overall rates of gene content evolution and sequence evolution. Absence of expression and gene loss among Clytia orthologues of genes patterning the anthozoan aboral pole, secondary axis and endomesoderm support simplification of planulae and polyps in Hydrozoa, including loss of bilateral symmetry. Consequently, although the polyp and planula are generally considered the ancestral cnidarian forms, in Clytia the medusa maximally deploys the ancestral cnidarian-bilaterian transcription factor gene complement.
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