Evidence map›Paper›PMID 30858571›Full record

ArticleNature microbiology2019

Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice.

Ryuta Uraki, Andrew K Hastings, Alejandro Marin-Lopez, Tomokazu Sumida, Takehiro Takahashi, Jonathan R Grover, Akiko Iwasaki, David A Hafler, Ruth R Montgomery, Erol Fikrig

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ryuta UrakiSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0890-1922
Andrew K HastingsSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Alejandro Marin-LopezSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Tomokazu SumidaDepartment of Neurology, School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-9806-2642
Takehiro TakahashiDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Jonathan R GroverDepartment of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, CT, USA.
Akiko IwasakiDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7824-9856
David A HaflerDepartment of Neurology, School of Medicine, Yale University, New Haven, CT, USA.
Ruth R MontgomeryDepartment of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA. erol.fikrig@yale.edu.ORCID http://orcid.org/0000-0002-5884-6047
Yale University · USHoward Hughes Medical Institute · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Systems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI David A. Hafler, RUTH R MONTGOMERY · 2010 to 2026
$50.4M
The role of NLRP6 and DHX15 in control of infection by RNA virusesR01AI127865 · NIAID · YALE UNIVERSITY · PI FIKRIG, EROL, FLAVELL, RICHARD A · 2018 to 2022
$2.1M
A novel vaccine against mosquito-borne Zika virus based on mosquito salivary gland protein AgBR1R41AI142846 · NIAID · L2 DIAGNOSTICS, LLC · PI FIKRIG, EROL · 2019 to 2020
$594k
Innate antiviral defense against Vaginal transmission of ZIKA virusR21AI131284 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2017 to 2018
$461k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI127865NIAID NIH HHS R21 AI131284NIAID NIH HHS R41 AI142846NIAID NIH HHS U19 AI089992
6 · The paper itself

Abstract

A recent epidemic of Zika virus in the Americas, affecting well over a million people, caused substantial mortality and morbidity, including Guillain-Barre syndrome, microcephaly and other fetal developmental defects

Indexed as

AedesAnimalsBacteriaDisease Models, AnimalFemaleGene SilencingInsect Bites and StingsMaleMiceMice, Inbred C57BLMosquito VectorsRecombinant ProteinsSalivaSalivary GlandsSalivary Proteins and PeptidesSkinRecombinant ProteinsSalivary Proteins and Peptides

Identifiers

PMID30858571
PMCPMC6533137
OpenAlexW2920868010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.