ArticleScientific reports2019
The dynamics of the antibiotic resistome in the feces of freshly weaned pigs following therapeutic administration of oxytetracycline.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 85 citations in OpenAlex.
- Age- and diet-driven assembly of the gut antibiotic resistome in humans and food-producing animals.Gut microbes · 2026Review
- Article
- Antimicrobial resistance genes in weaned pigs: quantitative abundance and group dynamics assessed by qPCR.Frontiers in veterinary science · 2025Article
- Resistomes from oxytetracycline-treated pigs are readily transferred to untreated pen mates.Animal microbiome · 2024Article
- Temporal dynamics of the fecal microbiome in female pigs from early life through estrus, parturition, and weaning of the first litter of piglets.Animal microbiome · 2024Article
- Fine-tuning of post-weaning pig microbiome structure and functionality by in-feed zinc oxide and antibiotics use.Frontiers in cellular and infection microbiology · 2024Review
- The effects of antibiotic use on the dynamics of the microbiome and resistome in pigs.Animal microbiome · 2023Article
- Insights on the effects of antimicrobial and heavy metal usage on the antimicrobial resistance profiles of pigs based on culture-independent studies.Veterinary research · 2023Review
- Age influences the temporal dynamics of microbiome and antimicrobial resistance genes among fecal bacteria in a cohort of production pigs.Animal microbiome · 2023Article
- Comparison of antibiotic resistance genes in swine manure storage pits of Iowa, USA.Frontiers in antibiotics · 2023Article
- Stability and volatility shape the gut bacteriome and Kazachstania slooffiae dynamics in preweaning, nursery and adult pigs.Scientific reports · 2022Article
- A longitudinal investigation of the effects of age, dietary fiber type and level, and injectable antimicrobials on the fecal microbiome and antimicrobial resistance of finisher pigs.Journal of animal science · 2022Article
- Novel Insights into the Pig Gut Microbiome Using Metagenome-Assembled Genomes.Microbiology spectrum · 2022Article
- Using Shotgun Sequencing to Describe the Changes Induced by In-Feed Zinc Oxide and Apramycin in the Microbiomes of Pigs One Week Postweaning.Microbiology spectrum · 2022Article
- The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.Microbiome · 2022Article
- Intestinal Exposure to Ceftiofur and Cefquinome after Intramuscular Treatment and the Impact of Ceftiofur on the Pig Fecal Microbiome and Resistome.Antibiotics (Basel, Switzerland) · 2022Article
- Use of genomics to explore AMR persistence in an outdoor pig farm with low antimicrobial usage.Microbial genomics · 2022Article
- Effect of amino acid blend as alternative to antibiotics for growing pigs.Journal of animal science · 2022Article
- Evaluation of the Impact of Antimicrobial Use Protocols in Porcine Reproductive and Respiratory Syndrome Virus-Infected Swine on Phenotypic Antimicrobial Resistance Patterns.Applied and environmental microbiology · 2022Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, shotgun metagenomics was employed to monitor the effect of oxytetracycline, administered at a therapeutic dose, on the dynamics of the microbiota and resistome in the feces of weaned pigs. Sixteen weaning pigs were assigned to one of two treatments including standard starter diet for 21 days or antibiotic-supplemented diet (10 g oxytetracycline/100 kg body weight/day) for 7 days, followed by 14 days of standard starter diet. Feces were collected from the pigs on days 0, 8, and 21 for microbiota and resistome profiling. Pigs receiving oxytetracycline exhibited a significantly greater richness (ANOVA, P = 0.034) and diversity (ANOVA, P = 0.048) of antibiotic resistance genes (ARGs) than the control pigs. Antibiotic administration significantly enriched the abundances of 41 ARGs, mainly from the tetracycline, betalactam and multidrug resistance classes. Compositional shifts in the bacterial communities were observed following 7 days of antibiotic adminstration, with the medicated pigs showing an increase in Escherichia (Proteobacteria) and Prevotella (Bacteroidetes) populations compared with the nonmedicated pigs. This might be explained by the potential of these taxa to carry ARGs that may be transferred to other susceptible bacteria in the densely populated gut environment. These findings will help in the optimization of therapeutic schemes involving antibiotic usage in swine production.
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