ArticleMucosal immunology2019
Host genotype and early life microbiota alterations have additive effects on disease susceptibility.
Article in Mucosal immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Application of edible fungi in gut microbiota regulation.NPJ science of food · 2025Review
- Article
- STAT1-mediated induction of Ly6c-expressing macrophages are involved in the pathogenesis of an acute colitis model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- High Red Meat Intake Exacerbates Dextran Sulfate-Induced Colitis by Altering Gut Microbiota in Mice.Frontiers in nutrition · 2021Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
Why do people develop chronic inflammatory illnesses, such as inflammatory bowel disease and auto-immunity, when they are adults? Is the trigger a recent exposure or may the seeds of the problem have formed much earlier in life? What is the role of genetic susceptibility in such processes?In this issue of Mucosal Immunology, Goethel et al. (Mucosal Immunol. 1, 2019) developed an experimental system in mice to provide at least partial answers to these important questions, in a model relevant to inflammatory bowel disease (IBD). To examine the role of host genotype, they compared wild type C57BL/6 mice with their congenic NOD2 knockouts, focusing on an important innate immunity gene related to detection of bacterial derived ligands and regulation of inflammatory immune responses (Gut Microbes 4:222-231, 2013). To examine the role of the microbiota, mice were exposed, or not, to amoxicillin, an antibiotic with broad-spectrum activity against the normal constituents of the mammalian intestinal microbiome. Further, to examine developmental phenomena related to host age, mice were exposed either during early life or as adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.