Evidence map›Paper›PMID 30858503›Full record

ArticleScientific reports2019

Interaction between CYP1A1/CYP17A1 polymorphisms and parental risk factors in the risk of hypospadias in a Chinese population.

Yaping Mao, Kang Zhang, Lin Ma, Xiaoyun Yun, Fengrong Ou, Ge Liu, Yi Yang, Yumin Zhang, Xiucong Pei, Zhiwen Duan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Role ofInternational journal of reproductive biomedicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yaping MaoDepartment of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Kang ZhangDepartment of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Lin MaDepartment of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Xiaoyun YunDepartment of Clinical Nutrition, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, China.
Fengrong OuDepartment of Clinical Nutrition, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, China.
Ge LiuDepartment of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.
Yi YangDepartment of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.
Yumin ZhangDepartment of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Xiucong PeiDepartment of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Zhiwen DuanDepartment of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China.
Mingyue MaDepartment of Toxicology, School of Public Heath, Shenyang Medical College, Shenyang, Liaoning Province, 110034, China. mymacmu@163.com.ORCID 0000-0003-4440-1618
Shenyang Medical College · CNChina Medical University · CNFirst Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypospadias (HS) is a common congenital malformation of the genitourinary tract in males and its etiology is viewed as multifactorial, and studies about gene-environment interaction in the etiology of HS are rare. A total of 152 cases and 151 controls were selected in the present study. Information before and during pregnancy from questionnaires finished by mothers of subjects were extracted, and the relating data were analyzed to determine the risk factors of HS. Meanwhile, maternal genomic DNA was genotyped for the single nucleotide polymorphisms (SNPs) of CYP1A1 rs1048943 and CYP17A1 rs4919686. Results of multivariable logistic regression analyses showed that several factors were associated with hypospadias risk. Analysis of the distributions of SNPs in CYP1A1 and CYP17A1 genes showed that the mutant genotype CC (OR = 4.87) of CYP1A1 rs1048943, and mutant genotype CC (OR = 5.82), recessive genotype AC + CC (OR = 2.17) and allele C (OR = 1.77) of CYP17A1 rs4919686 significantly increased the risk of HS. In addition, the additive gene-environment interactions were also found in several models. Several maternal risk factors that are associated with HS risk can interact with CYP1A1/CYP17A1 polymorphisms, which lead to infants vulnerable to occurrence of HS in Chinese populations.

Indexed as

Polymorphism, Single NucleotideAdolescentChildChinaCytochrome P-450 CYP1A1Gene-Environment InteractionHumansHypospadiasMaleSocioeconomic FactorsSteroid 17-alpha-HydroxylaseCYP17A1 protein, humanCYP1A1 protein, humanCytochrome P-450 CYP1A1Steroid 17-alpha-Hydroxylase

Identifiers

PMID30858503
PMCPMC6411735
OpenAlexW2921533590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.