ArticleScientific reports2019
Vibrio cholerae autoinducer-1 enhances the virulence of enteropathogenic Escherichia coli.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Milk-derived peptone reduces EHEC virulence by inhibiting the type III secretion system.Virulence · 2026Article
- Relay Architectures and Ecological Strategies of Quorum Sensing Effects on Microbial Interactions.Environmental microbiology · 2026Review
- Gut microbiome-derived indoles differentially suppress type III secretion system-associated virulence inFrontiers in microbiology · 2026Article
- Pathogen-pathogen interactions during co-infections.The ISME journal · 2025Review
- Constructions of quorum sensing signaling network for activated sludge microbial community.ISME communications · 2024Article
- Quorum sensing modulates bacterial virulence and colonization dynamics of the gastrointestinal pathogenGut microbes · 2023Article
- Conversations in the Gut: The Role of Quorum Sensing in Normobiosis.International journal of molecular sciences · 2023Review
- Breakdown of clonal cooperative architecture in multispecies biofilms and the spatial ecology of predation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Intestinal colonization againstAIMS microbiology · 2023Review
- Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting.Frontiers in microbiology · 2022Review
- Escherichia coli small molecule metabolism at the host-microorganism interface.Nature chemical biology · 2021Review
- Gut Microbiota and Diarrhea: An Updated Review.Frontiers in cellular and infection microbiology · 2021Review
- Modulation ofMicroorganisms · 2020Article
- Crosstalks Between Gut Microbiota andFrontiers in cellular and infection microbiology · 2020Review
- Article
- The Interface ofGut microbesReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrhoea is the second leading cause of death in children under the age of five. The bacterial species, Vibrio cholerae and enteropathogenic Escherichia coli (EPEC), are among the main pathogens that cause diarrhoeal diseases, which are associated with high mortality rates. These two pathogens have a common infection site-the small intestine. While it is known that both pathogens utilize quorum sensing (QS) to determine their population size, it is not yet clear whether potential bacterial competitors can also use this information. In this study, we examined the ability of EPEC to determine V. cholerae population sizes and to modulate its own virulence mechanisms accordingly. We found that EPEC virulence is enhanced in response to elevated concentrations of cholera autoinducer-1 (CAI-1), even though neither a CAI-1 synthase nor CAI-1 receptors have been reported in E. coli. This CAI-1 sensing and virulence upregulation response may facilitate the ability of EPEC to coordinate successful colonization of a host co-infected with V. cholerae. To the best of our knowledge, this is the first observed example of 'eavesdropping' between two bacterial pathogens that is based on interspecies sensing of a QS molecule.
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