ArticleScientific reports2019
Quantitative reconstruction of time-varying 3D cell forces with traction force optical coherence microscopy.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Double Sided Traction Force Microscopy: A Method to Confine Cells for Physiologically Relevant Force Measurements.Cytoskeleton (Hoboken, N.J.) · 2026Article
- Guidance for 3D traction force microscopy today and in the next decade.Nature methods · 2026Review
- 3D force microscopy for volumetric quantification of ultrasound-induced loading: applications for bone repair.Biomechanics and modeling in mechanobiology · 2025Article
- Three-dimensional traction technology and its application in mechanomedicine.Mechanobiology in medicine · 2025Review
- Field Guide to Traction Force Microscopy.Cellular and molecular bioengineering · 2024Review
- Precision Hydrogels for the Study of Cancer Cell Mechanobiology.Advanced healthcare materials · 2023Review
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Harnessing mechanobiology for kidney organoid research.Frontiers in cell and developmental biology · 2023Review
- Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging.Nature communications · 2022Article
- Impact of Doxorubicin on Cell-Substrate Topology.International journal of molecular sciences · 2022Article
- A primer to traction force microscopy.The Journal of biological chemistry · 2022Review
- Revisiting tissue tensegrity: Biomaterial-based approaches to measure forces across length scales.APL bioengineering · 2021Review
- Resolution-enhanced OCT and expanded framework of information capacity and resolution in coherent imaging.Scientific reports · 2021Article
- Soft Polymer-Based Technique for Cellular Force Sensing.Polymers · 2021Review
- Review
- Computational 4D-OCM for label-free imaging of collective cell invasion and force-mediated deformations in collagen.Scientific reports · 2021Article
- Obesity-associated Adipose Stromal Cells Promote Breast Cancer Invasion Through Direct Cell Contact and ECM Remodeling.Advanced functional materials · 2020Article
- Development of a 3-D Physical Dynamics Monitoring System Using OCM with DVC for Quantification of Sprouting Endothelial Cells Interacting with a Collagen Matrix.Materials (Basel, Switzerland) · 2020Article
- Three-dimensional imaging of cell and extracellular matrix elasticity using quantitative micro-elastography.Biomedical optics express · 2020Article
- Computed optical coherence microscopy of mouse brain ex vivo.Journal of biomedical optics · 2019Article
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Authors and funding
3 authors.
Funding
Abstract
Cellular traction forces (CTFs) play an integral role in both physiological processes and disease, and are a topic of interest in mechanobiology. Traction force microscopy (TFM) is a family of methods used to quantify CTFs in a variety of settings. State-of-the-art 3D TFM methods typically rely on confocal fluorescence microscopy, which can impose limitations on acquisition speed, volumetric coverage, and temporal sampling or coverage. In this report, we present the first quantitative implementation of a new TFM technique: traction force optical coherence microscopy (TF-OCM). TF-OCM leverages the capabilities of optical coherence microscopy and computational adaptive optics (CAO) to enable the quantitative reconstruction of 3D CTFs in scattering media with minute-scale temporal sampling. We applied TF-OCM to quantify CTFs exerted by isolated NIH-3T3 fibroblasts embedded in Matrigel, with five-minute temporal sampling, using images spanning a 500 × 500 × 500 μm
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