ArticleAnnals of family medicine2019
Identifying Adverse Drug Events in Older Community-Dwelling Patients.
Article in Annals of family medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Adverse Drug Reaction-Related Hospital Admissions and Adverse Drug Events and Their Association with Short- and Long-Term Health Outcomes in Older Adults.Geriatrics (Basel, Switzerland) · 2026Article
- Therapeutic Adherence in Cardiovascular Diseases: Insights from the Patient and Physician-A Narrative Review.Advances in therapy · 2026Review
- Adverse drug reactions and events in an Ageing PopulaTion risk Prediction (ADAPTiP) tool: the development and validation of a model for predicting adverse drug reactions and events in older patients.European geriatric medicine · 2025Article
- Prevalence and risk factors of self-reported adverse drug events in elderly co-morbid patients in northeastern China: a cross-sectional study.BMC geriatrics · 2025Article
- Article
- Co-Designing a Consumer-Focused Digital Reporting Health Platform to Improve Adverse Medicine Event Reporting: Protocol for a Multimethod Research Project (the ReMedi Project).JMIR research protocols · 2025Article
- The patient's perspectives of safe and routine proactive deprescribing in primary care for older people living with polypharmacy: a qualitative study.BMC geriatrics · 2024Article
- Drug-Drug Interactions and Their Association with Adverse Health Outcomes in the Older Community-Dwelling Population: A Prospective Cohort Study.Clinical drug investigation · 2024Article
- Adverse events associated with AstraZeneca COVID-19 vaccine among adults in Greater Kampala, Uganda: a cross-sectional study.African health sciences · 2024Article
- Adverse drug reactions and associated patient characteristics in older community-dwelling adults: a 6-year prospective cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Views on Suspected Adverse Drug Events in Older Adults with Chronic Conditions: A Qualitative Study.Patient preference and adherence · 2023Article
- Exploring Australian pharmacists' perceptions and practices towards reducing the risk of medicines-related harm in aged care residents.Frontiers in pharmacology · 2023Article
- Correlation between the number of patient-reported adverse events, adverse drug events, and quality of life in older patients: an observational study.International journal of clinical pharmacy · 2022Observational
- Adverse drug reactions in an ageing PopulaTion (ADAPT) study: Prevalence and risk factors associated with adverse drug reaction-related hospital admissions in older patients.Frontiers in pharmacology · 2022Article
- Evaluation of older persons' medications: a critical incident technique study exploring healthcare professionals' experiences and actions.BMC health services research · 2021Article
- Using INTERCheckDrugs - real world outcomes · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate a patient-report instrument for identifying adverse drug events (ADEs) in older populations with multimorbidity in the community setting.
methodsThis was a retrospective cohort study of 859 community-dwelling patients aged ≥70 years treated at 15 primary care practices. Patients were asked if they had experienced any of a list of 74 symptoms classified by physiologic system in the previous 6 months and if (1) they believed the symptom to be related to their medication, (2) the symptom had bothered them, (3) they had discussed it with their family physician, and (4) they required hospital care due to the symptom. Self-reported symptoms were independently reviewed by 2 clinicians who determined the likelihood that the symptom was an ADE. Family physician medical records were also reviewed for any report of an ADE.
resultsThe ADE instrument had an accuracy of 75% (95% CI, 77%-79%), a sensitivity of 29% (95% CI, 27%-31%), and a specificity of 93% (95% CI, 92%-94%). Older people who reported a symptom had an increased likelihood of an ADE (positive likelihood ratio [LR+]: 4.22; 95% CI, 3.78-4.72). Antithrombotic agents were the drugs most commonly associated with ADEs. Patients were most bothered by muscle pain or weakness (75%), dizziness or lightheadedness (61%), cough (53%), and unsteadiness while standing (52%). On average, patients reported 39% of ADEs to their physician. Twenty-six (3%) patients attended a hospital outpatient clinic, and 32 (4%) attended an emergency department due to ADEs.
conclusionOlder community-dwelling patients were often not correct in recognizing ADEs. The ADE instrument demonstrated good predictive value and could be used to differentiate between symptoms of ADEs and chronic disease in the community setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.