ArticleAnnals of family medicine2019
Systolic Blood Pressure and Cognitive Decline in Older Adults With Hypertension.
Article in Annals of family medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Disentangling the varying associations between systolic blood pressure and health outcomes in the very old: an individual patient data meta-analysis.Journal of hypertension · 2022Pooled it
- Trial
- Social factors associated with everyday functioning in older Black adults.Journal of the International Neuropsychological Society : JINS · 2025Article
- The role of multimorbidity in suspected dementia among elderly in Shanghai, China: a community-based cross-sectional study.Frontiers in psychiatry · 2025Article
- Neuropsychological and clinical variables associated with cognitive trajectories in patients with Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Efficacy of atorvastatin calcium on clinical manifestations and serum inflammatory markers in elderly patients with hypertension.American journal of translational research · 2024Article
- Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study.Alzheimer's research & therapy · 2023Article
- Using Machine Learning to Predict Cognitive Impairment Among Middle-Aged and Older Chinese: A Longitudinal Study.International journal of public health · 2023Article
- Hypertension, sleep quality, depression, and cognitive function in elderly: A cross-sectional study.Frontiers in aging neuroscience · 2023Article
- The Influence of 24-h Ambulatory Blood Pressure on Cognitive Function and Neuropathological Biomarker in Patients With Alzheimer's Disease.Frontiers in aging neuroscience · 2022Article
- Different hypertension thresholds and cognitive decline: a pooled analysis of three ageing cohorts.BMC medicine · 2021Article
- Physical Activity in Early- and Mid-Adulthood Are Independently Associated With Longitudinal Memory Trajectories in Later Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Frailty and hypertension in older adults: current understanding and future perspectives.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
- Blood Pressure Targets for Older Patients-Do Advanced Age and Frailty Really Not Matter?Canadian geriatrics journal : CGJ · 2020Article
- The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study.Frontiers in cardiovascular medicine · 2020Article
- Managing hypertension in frail oldest-old-The role of guideline use by general practitioners from 29 countries.PloS one · 2020Article
- Home Blood Pressure Monitoring in Cases of Clinical Uncertainty to Differentiate Appropriate Inaction From Therapeutic Inertia.Annals of family medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHypertension trials often exclude patients with complex health problems and lack generalizability. We aimed to determine if systolic blood pressure (SBP) in patients undergoing antihypertensive treatment is associated with 1-year changes in cognitive/daily functioning or quality of life (QoL) in persons aged ≥75 years with or without complex health problems.
methodsWe analyzed data from a population-based prospective cohort study (Integrated Systematic Care for Older Persons [ISCOPE]) with a 1-year follow-up. Stratified by SBP level in the year before baseline, we used mixed-effects linear regression models to evaluate the change from baseline to 1-year follow-up in outcome measures (Mini-Mental State Examination [MMSE], Groningen Activity Restriction Scale [GARS], and EQ-5D-3L). We adjusted for age, sex, and baseline MMSE/GARS/EQ-5D-3L scores and stratified for complex health problems as a proxy for frailty.
resultsParticipant (n = 1,266) age averaged 82.4 (SD 5) years, and 874 (69%) were women. For participants undergoing antihypertensive therapy (1,057; 83.5%) and with SBP <130 mm Hg, crude cognitive decline was 0.90 points MMSE, whereas in those with SBP >150 mm Hg, it was 0.14 points MMSE (ie, 0.76-point less decline;
conclusionsParticipants aged ≥75 years undergoing antihypertensive treatment, with SBP ≥130 mm Hg compared to <130 mm Hg, showed less cognitive decline after 1 year, without loss of daily functioning or QoL. This effect was strongest in participants with complex health problems. More studies should be conducted to determine if there is a causal relation and to understand the mechanism of the association observed.
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