Evidence map›Paper›PMID 30858237›Full record

ArticleG3 (Bethesda, Md.)2019

Whole Genome Sequencing and Progress Toward Full Inbreeding of the Mouse Collaborative Cross Population.

John R Shorter, Maya L Najarian, Timothy A Bell, Matthew Blanchard, Martin T Ferris, Pablo Hock, Anwica Kashfeen, Kathryn E Kirchoff, Colton L Linnertz, J Sebastian Sigmon and 3 more

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Low-coverage whole-genome sequencing facilitates accurate and cost-effective haplotype reconstruction in complex mouse crosses.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
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  6. Large differences in collateral blood vessel abundance among individuals arise from multiple genetic variants.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

John R ShorterDepartment of Genetics.ORCID 0000-0003-4732-5526
Maya L NajarianDepartment of Computer Science.
Timothy A BellDepartment of Genetics.ORCID 0000-0002-9546-6334
Matthew BlanchardDepartment of Genetics.
Martin T FerrisDepartment of Genetics.ORCID 0000-0003-1241-6268
Pablo HockDepartment of Genetics.
Anwica KashfeenDepartment of Computer Science.
Kathryn E KirchoffDepartment of Computer Science.
Colton L LinnertzDepartment of Genetics.
J Sebastian SigmonDepartment of Computer Science.
Darla R MillerDepartment of Genetics.
Leonard McMillanDepartment of Computer Science.
Fernando Pardo-Manuel de VillenaDepartment of Genetics fernando@med.unc.edu.ORCID 0000-0002-5738-5795

Funding

Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, HEISE, MARK T · 2012 to 2021
$36.6M
Resource Section - Core 001U42OD010924 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Folami Ideraabdullah · 2012 to 2026
$24.5M
Systems Genetics of TuberculosisP01AI132130 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2017 to 2021
$11.2M
Postdoctoral Research in Neurodevelopmental DisordersT32HD040127 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT, Mark D Shen · 2001 to 2026
$8.5M
Genomic Resources for the Collaborative CrossU24HG010100 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCMILLAN, LEONARD, PARDO-MANUEL DE VILLENA, FERNANDO · 2018 to 2022
$1.8M
NHGRI NIH HHS U24 HG010100NIAID NIH HHS P01 AI132130NIAID NIH HHS U19 AI100625NICHD NIH HHS T32 HD040127NIH HHS U42 OD010924
6 · The paper itself

Abstract

Two key features of recombinant inbred panels are well-characterized genomes and reproducibility. Here we report on the sequenced genomes of six additional Collaborative Cross (CC) strains and on inbreeding progress of 72 CC strains. We have previously reported on the sequences of 69 CC strains that were publicly available, bringing the total of CC strains with whole genome sequence up to 75. The sequencing of these six CC strains updates the efforts toward inbreeding undertaken by the UNC Systems Genetics Core. The timing reflects our competing mandates to release to the public as many CC strains as possible while achieving an acceptable level of inbreeding. The new six strains have a higher than average founder contribution from non-

Indexed as

Genetics, PopulationInbreedingWhole Genome SequencingAllelesAnimalsAnimals, Genetically ModifiedChromosome MappingCollaborative Cross MiceCrosses, GeneticGene FrequencyGenomeGenotypeMiceMice, Inbred StrainsGenomic PredictionGenPredheterozygosityinbreedingMPPMultiparent PopulationsShared data resourceswhole genome sequence

Identifiers

PMID30858237
PMCPMC6505143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.