ArticleAntimicrobial agents and chemotherapy2019
A Novel Small Molecule, ZY354, Inhibits Dental Caries-Associated Oral Biofilms.
Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Synergistic inhibition ofFrontiers in microbiology · 2026Article
- Effects of Berberine chloride hydrate on cariogenic multispecies streptococcal biofilm.Journal of oral microbiology · 2026Article
- Cordycepin affects Streptococcus mutans biofilm and interferes with its metabolism.BMC oral health · 2025Article
- Anti-caries effect of a novel elastic silicone appliance material incorporating sodium fluoride.Frontiers in microbiology · 2024Article
- Metronidazole and Ketoprofen-Loaded Mesoporous Magnesium Carbonate for Rapid Treatment of Acute PeriodontitisACS omega · 2023Article
- Regulatory Effect of Irresistin-16 on Competitive Dual-Species Biofilms Composed ofPathogens (Basel, Switzerland) · 2022Article
- The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application.BioMed research international · 2022Review
- The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases.Frontiers in cellular and infection microbiology · 2022Review
- Novel antimicrobial agents targeting theFrontiers in cellular and infection microbiology · 2022Review
- Small molecule targeting amyloid fibrils inhibits Streptococcus mutans biofilm formation.AMB Express · 2021Article
- Small Molecule Compounds, A Novel Strategy againstPathogens (Basel, Switzerland) · 2021Review
- Antibiofilm Potential of Medicinal Plants againstAntibiotics (Basel, Switzerland) · 2021Review
- Antimicrobial activities of a small molecule compound II-6s against oral streptococci.Journal of oral microbiology · 2021Article
- A Novel Small Molecule, LCG-N25, Inhibits Oral Streptococcal Biofilm.Frontiers in microbiology · 2021Article
- A small molecule II-6s inhibitsJournal of oral microbiology · 2021Article
- Design and synthesis of novel spirooxindole-indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors.Molecular diversity · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilm control is a critical approach to the better management of dental caries. Antimicrobial small molecules have shown their potential in the disruption of oral biofilm and control of dental caries. The objectives of this study were to examine the antimicrobial activity and cytotoxicity of a newly designed small-molecule compound, ZY354. ZY354 was synthesized, and its cytotoxicity was evaluated in human oral keratinocytes (HOK), human gingival epithelial cells (HGE), and macrophages (RAW) by CCK-8 assays. Minimal inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), minimum biofilm inhibition concentrations (MBICs), and minimum biofilm reduction concentrations (MBRCs) of ZY354 against common oral streptococci (i.e.,
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Registered trials
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