ArticleJournal of immunology (Baltimore, Md. : 1950)2019
TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
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In one paragraph
Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 67 citations in OpenAlex.
- Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells.The Journal of clinical investigation · 2022Trial
- T Cell Thoughts.Immunological reviews · 2026Review
- The spontaneous neoantigen-specific CD4Journal for immunotherapy of cancer · 2025Article
- Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy-Supportive Phenotype In Vitro.European journal of immunology · 2025Article
- CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.Nature communications · 2025Article
- TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R-BCL6 signaling nexus.Science immunology · 2025Article
- CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.bioRxiv : the preprint server for biology · 2025Article
- From mechanisms to therapies: the multifaceted roles of guanylate-binding protein 2 in immunity, cancer, and beyond.Frontiers in immunology · 2025Review
- CD4Nature communications · 2024Article
- Low-affinity CD8American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Innate-like T cell subset commitment in the murine thymus is independent of TCR characteristics and occurs during proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Challenges in developing personalized neoantigen cancer vaccines.Nature reviews. Immunology · 2024Review
- TCR-CD3 signal strength regulates plastic coexpression of IL-4 and IFN-γ in Tfh-like cells.Frontiers in immunology · 2024Article
- Systems immunology of regulatory T cells: can one circuit explain it all?Trends in immunology · 2023Review
- Ethanolic Extract from Seed Residues of Sea Buckthorn (Foods (Basel, Switzerland) · 2023Article
- CD4 Effector TCR Avidity for Peptide on APC Determines the Level of Memory Generated.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- CD4Nature immunology · 2023Review
- COVID-19 relapse associated with SARS-CoV-2 evasion from CD4iScience · 2023Article
- T-helper cells flexibility: the possibility of reprogramming T cells fate.Frontiers in immunology · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Dmitri I KotovDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0001-7843-1503
Jason S MitchellCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.
Thomas PengoUniversity of Minnesota Informatics Institute, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-9632-918X
Christiane RuedlSchool of Biological Sciences, Nanyang Technological University, Singapore 637551.ORCID 0000-0002-5599-6541
Sing Sing WayDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229; and.
Ryan A LangloisDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455.
Brian T FifeCenter for Immunology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0001-9826-5637
Marc K JenkinsDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455; jenki002@umn.edu.ORCID 0000-0001-8009-7655
University of Minnesota · USCincinnati Children's Hospital Medical Center · USNanyang Technological University · SG
Funding
Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4MType I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HOGQUIST, KRISTIN A. · 1993 to 2023
$31.1MTRACKING CD4+ MEMORY T CELLS IN VIVOR01AI039614 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JENKINS, MARC KEVIN · 1996 to 2023
$8.7MIMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7MImmunological identity redefined by genetically foreign microchimeric cellsDP1AI131080 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2020
$5.5MMinnesota Training Program in VirologyT32AI083196 · NIAID · UNIVERSITY OF MINNESOTA · PI Louis M Mansky · 2010 to 2026
$3.2MFunctional immune tolerance to non-inherited maternal antigenR01AI124657 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2017 to 2021
$1.9MMaternal Regulatory T cell antigen-specificityR01AI120202 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WAY, SING SING · 2016 to 2020
$1.9MMechanisms of immune tolerance in autoimmune diabetesR01AI106791 · NIAID · UNIVERSITY OF MINNESOTA · PI FIFE, BRIAN T · 2014 to 2018
$1.9MNCI NIH HHS P30 CA077598NIAID NIH HHS DP1 AI131080NIAID NIH HHS P01 AI035296NIAID NIH HHS R01 AI039614NIAID NIH HHS R01 AI106791NIAID NIH HHS R01 AI120202NIAID NIH HHS R01 AI124657NIAID NIH HHS T32 AI007313NIAID NIH HHS T32 AI083196
Abstract
Naive CD4
Indexed as
AnimalsCell DifferentiationDendritic CellsGene Expression RegulationGTP-Binding ProteinsInterleukin-2 Receptor alpha SubunitMiceMice, KnockoutPeptide Elongation FactorsReceptors, Antigen, T-CellSignal TransductionTh1 CellsTh2 CellsGbp2 protein, mouseGTP-Binding ProteinsIl2ra protein, mouseInterleukin-2 Receptor alpha SubunitPeptide Elongation FactorsReceptors, Antigen, T-Cell
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.