Evidence map›Paper›PMID 30858183›Full record

ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2019

Nephrology consultation and mortality in people with stage 4 chronic kidney disease: a population-based study.

Ping Liu, Robert R Quinn, Mohammad Ehsanul Karim, Aminu Bello, Helen Tam-Tham, Robert Weaver, Paul E Ronksley, Hude Quan, Giovanni F M Strippoli, Braden Manns and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Comorbidity, life-style factors and healthcare utilization in incident chronic kidney disease: sex-specific analyses of claims data.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Observational
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  12. Article
  13. The Impact of a New Triage and Booking System on Renal Clinic Wait Times.Canadian journal of kidney health and disease · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ping LiuDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Robert R QuinnDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Mohammad Ehsanul KarimDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Aminu BelloDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Helen Tam-ThamDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Robert WeaverDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Paul E RonksleyDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Hude QuanDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Giovanni F M StrippoliDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Braden MannsDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Brenda R HemmelgarnDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Marcello TonelliDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy.
Pietro RavaniDepartments of Medicine and Community Health Sciences (Liu, Quinn, Tam-Tham, Weaver, Ronksley, Quan, Manns, Hemmelgarn, Tonelli, Ravani), University of Calgary, Calgary, Alta.; School of Population and Public Health (Karim), The University of British Columbia; Department of Medicine (Bello), University of Alberta, Edmonton, Alta.; Department of Emergency and Organ Transplantation (Strippoli), University of Bari, Bari, Italy pravani@ucalgary.ca.
University of British Columbia · CAUniversity of Bari Aldo Moro · ITUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGuidelines recommend nephrology referral for people with advanced non-dialysis-dependent chronic kidney disease, based mostly on survival benefits seen in retrospective studies of dialysis patients, which may not be generalizable to the broader population with chronic kidney disease. We aimed to examine the association between outpatient nephrology consultation and survival in adults with stage 4 chronic kidney disease.

methodsWe linked population-based laboratory and administrative data from 2002 to 2014 in Alberta, Canada, on adults with stage 4 chronic kidney disease (sustained estimated glomerular filtration rate ≥ 15 to < 30 mL/min/1.73 m

resultsOf the 14 382 study participants (median follow-up 2.7 yr), 64% were aged ≥ 80 years, 35% saw a nephrologist and 66% died during follow-up. Nephrology consultation was associated with lower mortality (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.82-0.93). The association was strongest in people < 70 years (HR 0.78, 95% CI, 0.65-0.92), progressively weaker with increasing age, and absent in people ≥ 90 years (HR 1.05, 95% CI 0.88-1.25).

interpretationThe survival benefit of nephrology consultation in adults with stage 4 chronic kidney disease may be smaller than expected and appears to attenuate with increasing age. These findings should inform recommendations for nephrology referral considering the advanced age of the patient population meeting current referral criteria.

Indexed as

Referral and ConsultationAdolescentAdultAgedAged, 80 and overAlbertaAmbulatory CareFemaleHumansMaleMiddle AgedNephrologyPopulation SurveillanceRenal Insufficiency, ChronicYoung Adult

Identifiers

PMID30858183
PMCPMC6411473
OpenAlexW2921871033

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.