Evidence map›Paper›PMID 30858176›Full record

ArticleThe Journal of biological chemistry2019

A complex containing the

Andrew C Giles, Muriel Desbois, Karla J Opperman, Rubens Tavora, Marissa J Maroni, Brock Grill

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  11. CanPharmaceuticals (Basel, Switzerland) · 2024
    Review
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  15. Article
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  19. Atropine reduces aldicarb-induced sensitivity tomicroPublication biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrew C GilesFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and.ORCID 0000-0002-0875-0696
Muriel DesboisFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and.
Karla J OppermanFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and.
Rubens Tavorathe Harriet L. Wilkes Honors College, Florida Atlantic University, Jupiter, Florida 33458.
Marissa J MaroniFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and.
Brock GrillFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and bgrill@scripps.edu.ORCID 0000-0002-0379-3267
Scripps Research Institute · USFlorida Atlantic University · US

Funding

Mechanisms of synapse formation and axon termination in C. elegansR01NS072129 · NINDS · UNIVERSITY OF MINNESOTA · PI GRILL, BROCK · 2011 to 2024
$8.0M
NINDS NIH HHS R01 NS072129
6 · The paper itself

Abstract

Inhibitory GABAergic transmission is required for proper circuit function in the nervous system. However, our understanding of molecular mechanisms that preferentially influence GABAergic transmission, particularly presynaptic mechanisms, remains limited. We previously reported that the ubiquitin ligase EEL-1 preferentially regulates GABAergic presynaptic transmission. To further explore how EEL-1 functions, here we performed affinity purification proteomics using

Indexed as

AldicarbAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsChromatography, AffinityGABAergic NeuronsN-AcetylglucosaminyltransferasesPresynaptic TerminalsProtein BindingProteomicsSignal TransductionSynaptic TransmissionUbiquitin-Protein LigasesAldicarbCaenorhabditis elegans ProteinsEEL-1 protein, C elegansN-Acetylglucosaminyltransferasesogt-1 protein, C elegansUbiquitin-Protein LigasesCaenorhabditis elegans (C. elegans)E3 ubiquitin ligaseEEL-1GABAergic transmissiongamma-aminobutyric acid (GABA)HUWE1motor neuronneurotransmissionOGT-1O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT)proteomicssynapse

Identifiers

PMID30858176
PMCPMC6497937
OpenAlexW2921813312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.