ArticleJournal of genetics and genomics = Yi chuan xue bao2019
mTOR-S6K1 pathway mediates cytoophidium assembly.
Article in Journal of genetics and genomics = Yi chuan xue bao, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- AP-3 and the V-ATPase modulate CTP synthase assembly through spatial association at the yeast vacuole.Molecular biology of the cell · 2026Article
- Integrative role of CTPS cytoophidia in polyploid tissue growth and nutrient adaptation.Insect science · 2026Article
- EphB4 inhibition defines a druggable synthetic-lethal vulnerability in MYC-driven triple-negative breast cancer.Cell death & disease · 2026Article
- Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.Advances in experimental medicine and biology · 2026Review
- Differential Cytoophidium Assembly betweenInternational journal of molecular sciences · 2024Article
- The Impact of Developmental and Metabolic Cues on Cytoophidium Formation.International journal of molecular sciences · 2024Review
- Cytoophidia: a conserved yet promising mode of enzyme regulation in nucleotide metabolism.Molecular biology reports · 2024Review
- Connecting Hippo Pathway and Cytoophidia inInternational journal of molecular sciences · 2024Article
- Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation.Life science alliance · 2023Article
- Structural basis of human PRPS2 filaments.Cell & bioscience · 2023Article
- Cytoophidia Maintain the Integrity ofInternational journal of molecular sciences · 2022Article
- CTP synthase: the hissing of the cellular serpent.Histochemistry and cell biology · 2022Review
- High Concentration of FBS Can Save mTOR Down-Regulation Caused byVeterinary sciences · 2022Article
- Super-Resolution Imaging Reveals Dynamic Reticular Cytoophidia.International journal of molecular sciences · 2022Article
- Cytoophidia coupling adipose architecture and metabolism.Cellular and molecular life sciences : CMLS · 2022Article
- Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation.Cellular and molecular life sciences : CMLS · 2022Article
- Article
- Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells.Cancer research · 2022Article
- Recent advances of the mammalian target of rapamycin signaling in mesenchymal stem cells.Frontiers in genetics · 2022Review
- Highly effective proximate labeling in Drosophila.G3 (Bethesda, Md.) · 2021Article
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Authors and funding
2 authors.
Funding
Abstract
CTP synthase (CTPS), the rate-limiting enzyme in de novo CTP biosynthesis, has been demonstrated to assemble into evolutionarily conserved filamentous structures, termed cytoophidia, in Drosophila, bacteria, yeast and mammalian cells. However, the regulation and function of the cytoophidium remain elusive. Here, we provide evidence that the mechanistic target of rapamycin (mTOR) pathway controls cytoophidium assembly in mammalian and Drosophila cells. In mammalian cells, we find that inhibition of mTOR pathway attenuates cytoophidium formation. Moreover, CTPS cytoophidium assembly appears to be dependent on the mTOR complex 1 (mTORC1) mainly. In addition, knockdown of the mTORC1 downstream target S6K1 can inhibit cytoophidium formation, while overexpression of the constitutively active S6K1 reverses mTOR knockdown-induced cytoophidium disassembly. Finally, reducing mTOR protein expression results in a decrease of the length of cytoophidium in Drosophila follicle cells. Therefore, our study connects CTPS cytoophidium formation with the mTOR signaling pathway.
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Registered trials
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