ReviewInsect biochemistry and molecular biology2019
Regulation of the Drosophila Imd pathway by signaling amyloids.
Review in Insect biochemistry and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Functional amyloids as molecular switches: emerging roles in diverse signalling pathways.Biochemical Society transactions · 2026Review
- Caffeic Acid Protects Against Ulcerative Colitis via Inhibiting Mitochondrial Apoptosis and Immune Overactivation inDrug design, development and therapy · 2025Article
- The localization of Toll and Imd pathway and complement system components and their response to Vibrio infection in the nemertean Lineus ruber.BMC biology · 2023Article
- Article
- In the battle of the disease: a transcriptomic analysis of European foulbrood-diseased larvae of the Western honey bee (Apis mellifera).BMC genomics · 2022Article
- The Intestinal Immune Defense System in Insects.International journal of molecular sciences · 2022Review
- Dynamic Regulation of NF-κB Response in Innate Immunity: The Case of the IMD Pathway in Drosophila.Biomedicines · 2022Review
- Ecdysone signaling mediates the trade-off between immunity and reproduction via suppression of amyloids in the mosquito Aedes aegypti.PLoS pathogens · 2022Article
- Protein Phosphatase 4 Negatively Regulates the Immune Deficiency-NF-κB Pathway during theJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex.Immunity · 2021Article
- Drosophila H2Av negatively regulates the activity of the IMD pathway via facilitating Relish SUMOylation.PLoS genetics · 2021Article
- PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.International journal of molecular sciences · 2021Article
- Article
- Deleted in azoospermia-associated protein 2 regulates innate immunity by stimulating Hippo signaling in crab.The Journal of biological chemistry · 2019Article
- Gut microbes, ageing & organ function: a chameleon in modern biology?EMBO molecular medicine · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-κB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.