Evidence map›Paper›PMID 30857601›Full record

ReviewBritish journal of anaesthesia2019

Propofol infusion syndrome: a structured literature review and analysis of published case reports.

Scott Hemphill, Luke McMenamin, Mark C Bellamy, Philip M Hopkins

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in British journal of anaesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06095570 (The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal), which is not on this map. Cited by 138 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 5 pooled it
43.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06095570 phase4unknown statusnot on this mapstarted 2022, after this paper: background citation

The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal

TypeinterventionalSponsorThe Second Affiliated Hospital of Hainan Medical UniversityRan2022 to 2023Enrolled150ConditionsIntubation, Intratracheal, Adverse EffectsArmsCiprofol, Remimazolam
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 5 syntheses or guidelines pooled it, 308 citations in OpenAlex.

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  17. Characterizing the Safety and Efficacy of Propofol in Critically Ill Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Scott HemphillSchool of Medicine, University of Leeds, Leeds, UK.
Luke McMenaminLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Department of Anaesthesia, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Mark C BellamyLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Department of Anaesthesia, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK; Intensive Care Unit, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Philip M HopkinsLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Department of Anaesthesia, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address: p.m.hopkins@leeds.ac.uk.
University of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Propofol infusion syndrome is a rare, potentially fatal condition first described in children in the 1990s and later reported in adults. We provide a narrative review of what is currently known about propofol infusion syndrome, including a structured analysis of all published case reports; child and adult cases were analysed separately as propofol is no longer used for long-term sedation in children. The review contains an update on current knowledge of the pathophysiology of this condition along with recommendations for its diagnosis, prevention, and management. We reviewed 108 publications documenting 168 cases of propofol infusion syndrome. We evaluated clinical features and analysed factors influencing mortality in child and adult cases using separate multivariate analysis models. We used separate multiple linear regression models to analyse relationships between cumulative dose of propofol and the number of features seen and organ systems involved. Lipidaemia, fever, and hepatomegaly occurred more frequently in children than in adults, whilst rhabdomyolysis and hyperkalaemia were more frequent in adults. Mortality from propofol infusion syndrome is independently associated with fever and hepatomegaly in children, and electrocardiogram changes, hypotension, hyperkalaemia, traumatic brain injury, and a mean propofol infusion rate >5 mg kg

Indexed as

Age FactorsAnesthetics, IntravenousDose-Response Relationship, DrugHumansHypnotics and SedativesPropofolPropofol Infusion SyndromeRisk FactorsAnesthetics, IntravenousHypnotics and SedativesPropofoladultchildcritical carehaemofiltrationpropofolpropofol infusion syndromerhabdomyolysis, sedation

Identifiers

PMID30857601
PMCPMC6435842
OpenAlexW2913552155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.