Evidence map›Paper›PMID 30857464›Full record

Trial reportJournal of the American Heart Association2019

Impact of Diabetes Mellitus and Chronic Kidney Disease on Cardiovascular Outcomes and Platelet P2Y

Francesco Franchi, Stefan K James, Tatevik Ghukasyan Lakic, Andrzej J Budaj, Jan H Cornel, Hugo A Katus, Matyas Keltai, Frederic Kontny, Basil S Lewis, Robert F Storey and 4 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Antiplatelet agents for chronic kidney disease.The Cochrane database of systematic reviews · 2022
    Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Clopidogrel-Mediated P2YJACC. Basic to translational science · 2024
    Article
  11. Review
  12. Impact of chronic kidney disease and diabetes on clinical outcomes in women undergoing PCI.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023
    Review
  13. Article
  14. Review
  15. Ideal P2Y12 Inhibitor in Acute Coronary Syndrome: A Review and Current Status.International journal of environmental research and public health · 2022
    Review
  16. Review
  17. Article
  18. Review
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 9 countries.

Francesco Franchi1 University of Florida, College of Medicine-Jacksonville Jacksonville FL.
Stefan K James2 Department of Medical Sciences Cardiology Uppsala University Uppsala Sweden.
Tatevik Ghukasyan Lakic3 Uppsala Clinical Research Center Uppsala University Uppsala Sweden.
Andrzej J Budaj4 Postgraduate Medical School Grochowski Hospital Warsaw Poland.
Jan H Cornel5 Department of Cardiology Noordwest Ziekenhuisgroep Alkmaar Netherlands.
Hugo A Katus6 Medizinishe Klinik Universitätsklinikum Heidelberg Heidelberg Germany.
Matyas Keltai7 Hungarian Institute of Cardiology Semmelweis University Budapest Hungary.
Frederic Kontny8 Department of Cardiology Stavanger University Hospital Stavanger Norway.
Basil S Lewis9 Lady Davis Carmel Medical Center Haifa Israel.
Robert F Storey10 Department of Infection, Immunity and Cardiovascular Disease University of Sheffield United Kingdom.
Anders Himmelmann11 AstraZeneca, Research and Development Gothenburg Sweden.
Lars Wallentin2 Department of Medical Sciences Cardiology Uppsala University Uppsala Sweden.
Dominick J Angiolillo1 University of Florida, College of Medicine-Jacksonville Jacksonville FL.
PLATO Investigators
Uppsala University · SEAstraZeneca (Netherlands) · NLCarmel Medical Center · ILFlorida College · USGrochowski Hospital · PLHeidelberg University · DENoordwest Ziekenhuisgroep · NLSemmelweis University · HUStavanger University Hospital · NOUniversity of Florida · USUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background There are limited data on how the combination of diabetes mellitus ( DM ) and chronic kidney disease ( CKD ) affects cardiovascular outcomes as well as response to different P2Y

Indexed as

Acute Coronary SyndromeAgedClopidogrelComorbidityDiabetes MellitusDose-Response Relationship, DrugElectrocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedPlatelet Aggregation InhibitorsPrognosisPurinergic P2Y Receptor AntagonistsRenal Insufficiency, ChronicClopidogrelPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsTicagreloracute coronary syndromechronic kidney diseaseclopidogreldiabetes mellitusticagrelor

Identifiers

PMID30857464
PMCPMC6475041
OpenAlexW2920957477

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.