Evidence map›Paper›PMID 30857246›Full record

ArticleMarine drugs2019

Target Identification of the Marine Natural Products Dictyoceratin-A and -C as Selective Growth Inhibitors in Cancer Cells Adapted to Hypoxic Environments.

Takashi Kawachi, Shun Tanaka, Akinori Fukuda, Yuji Sumii, Andi Setiawan, Naoyuki Kotoku, Motomasa Kobayashi, Masayoshi Arai

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

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  7. R2TP/PAQosome as a promising chemotherapeutic target in cancer.The Japanese dental science review · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Takashi KawachiGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. pabro-ai@hotmail.co.jp.
Shun TanakaGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. tanaka.eclipse@gmail.com.
Akinori FukudaGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. sukoshi1293fushigi@yahoo.co.jp.
Yuji SumiiGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. sumii.yuji@nitech.ac.jp.
Andi SetiawanDepartment of Chemistry, Faculty of Science, Lampung University, J1. Prof. Dr. Sumantri Brodjonegoro No. 1, Bandar Lampung 35145, Indonesia. asetiawan0922@gmail.com.
Naoyuki KotokuGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. kotoku@fc.ritsumei.ac.jp.
Motomasa KobayashiGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. kobayasi@phs.osaka-u.ac.jp.
Masayoshi AraiGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. araim@phs.osaka-u.ac.jp.
The University of Osaka · JPLampung University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia-adapted cancer cells in tumors contribute to the pathological progression of cancer. The marine spongean sesquiterpene phenols dictyoceratin-A (

Indexed as

PoriferaAnimalsAntineoplastic AgentsApoptosis Regulatory ProteinsBiological ProductsCarrier ProteinsCell HypoxiaCell Line, TumorGene Knockdown TechniquesHumansHydroxybenzoatesMolecular Targeted TherapyNeoplasmsRNA, Small InterferingSesquiterpenesAntineoplastic AgentsApoptosis Regulatory ProteinsBiological ProductsCarrier Proteinsdictyoceratin-CHydroxybenzoatesRNA, Small InterferingRPAP3 protein, humanSesquiterpenessmenospondiolcancerdictyoceratin-Ahypoxiaprobe moleculeRNA polymerase II-associated protein 3target molecule

Identifiers

PMID30857246
PMCPMC6471994
OpenAlexW2921146493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.