ArticleInternational journal of molecular sciences2019
Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Analysis of the evolution of placental oxidative stress research from a bibliometric perspective.Frontiers in pharmacology · 2024Pooled it
- Nutri-Epigenetic Effects of Phenolic Compounds from Extra Virgin Olive Oil: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Epigenetic Modifications Induced by Olive Oil and Its Phenolic Compounds: A Systematic Review.Molecules (Basel, Switzerland) · 2021Pooled it
- Effects of Undernutrition and Hydroxytyrosol Supplementation in Late Pregnancy on Growth and Metabolic and Endocrine Profiles of Male Beef Offspring During the Fattening Phase.Animals : an open access journal from MDPI · 2026Article
- Geroprotective applications of oleuropein and hydroxytyrosol through the hallmarks of ageing.GeroScience · 2026Review
- Altered Lipid Profile and Oxidative Stress During Pregnancy: Impact on the Fetus and Risk of Metabolic Disorders in Adulthood.International journal of molecular sciences · 2026Review
- Paternal and/or Maternal Blackberry (Antioxidants (Basel, Switzerland) · 2025Article
- Impact of maternal antioxidant supplementation on ovarian development in prepuberal Iberian pig offspring.Translational animal science · 2025Article
- Natural plant polyphenols contribute to the ecological and healthy swine production.Journal of animal science and biotechnology · 2024Review
- Article
- Chronic Undernutrition in Ovine Twin Pregnancies Abolishes Differences in Birth Weight Due to Sex: An Evaluation of the Role of Nutritional and Antioxidant Supplementation.Animals : an open access journal from MDPI · 2024Article
- Long-Term Effect of Maternal Antioxidant Supplementation on the Lipid Profile of the Progeny According to the Sow's Parity Number.Antioxidants (Basel, Switzerland) · 2024Article
- Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model.Journal of animal science and biotechnology · 2024Article
- Accurate models and nutritional strategies for specific oxidative stress factors: Does the dose matter in swine production?Journal of animal science and biotechnology · 2024Review
- Chemical-functional characterization ofFrontiers in veterinary science · 2024Article
- Maternal dietary antioxidant supplementation regulates weaned piglets' adipose tissue transcriptome and morphology.PloS one · 2024Article
- Plant-derived polyphenols in sow nutrition: An update.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
- Antioxidant Intervention to Improve Cognition in the Aging Brain: The Example of Hydroxytyrosol and Resveratrol.International journal of molecular sciences · 2022Review
- Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Prenatal Effects on Fetal Fatty Acid Composition in the Iberian Pig.Animals : an open access journal from MDPI · 2022Article
- Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model.Antioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 4 countries.
Funding
Abstract
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.