Evidence map›Paper›PMID 30857168›Full record

ArticleJournal of clinical medicine2019

Effects of Oral Anticoagulant Therapy on Gene Expression in Crosstalk between Osteogenic Progenitor Cells and Endothelial Cells.

Luca Dalle Carbonare, Monica Mottes, Anna Brunelli, Michela Deiana, Samuele Cheri, Silvia Suardi, Maria Teresa Valenti

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Anticoagulants and Osteoporosis.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Luca Dalle CarbonareDepartment of Medicine, University of Verona, Pz.le Scuro 10, 37134 Verona, Italy. luca.dallecarbonare@univr.it.ORCID 0000-0003-3263-6671
Monica MottesDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. monica.mottes@univr.it.ORCID 0000-0002-7390-2246
Anna BrunelliDepartment of Medicine, University of Verona, Pz.le Scuro 10, 37134 Verona, Italy. anna.brunelli@univr.it.
Michela DeianaDepartment of Medicine, University of Verona, Pz.le Scuro 10, 37134 Verona, Italy. michela.deiana@univr.it.ORCID 0000-0001-7595-2346
Samuele CheriDepartment of Medicine, University of Verona, Pz.le Scuro 10, 37134 Verona, Italy. samuele.cheri@univr.it.ORCID 0000-0001-8519-8148
Silvia SuardiDepartment of Medicine, University of Verona, Pz.le Scuro 10, 37134 Verona, Italy. silvia.suardi@univr.it.
Maria Teresa ValentiDepartment of Medicine, University of Verona, Pz.le Scuro 10, 37134 Verona, Italy. mariateresa.valenti@univr.it.ORCID 0000-0003-1166-8033
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct oral anti-coagulants (DOACs) are employed in clinical practice for the prevention and treatment of recurrent venous thromboembolism and for the prevention of stroke in non-valvular atrial fibrillation. DOACs directly and reversibly inhibit activated factor X or thrombin and can interfere with other pathophysiological processes such as inflammation, lipid metabolism, and bone turnover. We aimed to evaluate the possible effects of DOACs on osteogenesis and angiogenesis. We treated 34 patients affected by cardiovascular disorders with DOACs; biochemical and molecular analyses were performed before and after three months of treatment. Circulating progenitors (CPs; CD34

Indexed as

anticoagulantscirculating progenitorsgene expressionosteogenesis

Identifiers

PMID30857168
PMCPMC6462930
OpenAlexW2922112065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.