ArticleMolecules (Basel, Switzerland)2019
Synergistic Hypoglycemic Effects of Pumpkin Polysaccharides and Puerarin on Type II Diabetes Mellitus Mice.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- A Fiber- and Plant-Based Nutraceutical Attenuates Insulin Resistance and Oxidative Stress in Type 2 Diabetic Mice.Nutrients · 2026Article
- Therapeutic potential of traditional Chinese medicine and mechanisms for the treatment of type 2 diabetes mellitus.Chinese medicine · 2025Review
- Network pharmacology-based study on the mechanism of Tangfukang formula against type 2 diabetes mellitus.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review.Nutrients · 2024Review
- Hypoglycemic Effect of Polysaccharides fromBiology · 2024Article
- A New Potent Inhibitor against α-Glucosidase Based on an In Vitro Enzymatic Synthesis Approach.Molecules (Basel, Switzerland) · 2024Article
- Puerarin inhibits HDAC1-induced oxidative stress disorder by activating JNK pathway and alleviates acrolein-induced atherosclerosis.Clinics (Sao Paulo, Brazil) · 2024Article
- Preventive Effect ofNutrients · 2023Article
- Beyond cellulose: pharmaceutical potential for bioactive plant polysaccharides in treating disease and gut dysbiosis.Frontiers in microbiology · 2023Review
- Polysaccharides from natural resource: ameliorate type 2 diabetes mellitus via regulation of oxidative stress network.Frontiers in pharmacology · 2023Review
- Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway.Frontiers in nutrition · 2023Review
- Fucoidan fromFoods (Basel, Switzerland) · 2022Article
- A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities.Foods (Basel, Switzerland) · 2022Review
- Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review.Foods (Basel, Switzerland) · 2022Review
- Nutritional Value, Phytochemical Potential, and Therapeutic Benefits of Pumpkin (Plants (Basel, Switzerland) · 2022Review
- The antihyperglycemic effect of pulsed electric field-extracted polysaccharide ofFrontiers in nutrition · 2022Article
- Puerarin improves diabetic wound healing via regulation of macrophage M2 polarization phenotype.Burns & trauma · 2022Article
- Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway.Molecular medicine reports · 2021Article
- New insight into the joint significance of dietary jujube polysaccharides and 6-gingerol in antioxidant and antitumor activities.RSC advances · 2021Article
- Innovative Technologies for Extraction and Microencapsulation of Bioactives from Plant-Based Food Waste and their Applications in Functional Food Development.Foods (Basel, Switzerland) · 2021Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the hypoglycemic effect and potential mechanism of pumpkin polysaccharides and puerarin on type II diabetes mellitus (T2DM) mice, mice were fed a high-fat diet and injected intraperitoneally with streptozotacin to induce T2DM. After eight weeks of drug administration, blood samples were withdrawn from tail veins of mice that had been fasted overnight. The results showed that both pumpkin polysaccharides and puerarin, as well as a pumpkin polysaccharides and puerarin combination, could ameliorate T2DM. The pumpkin polysaccharides and puerarin combination had a synergetic hypoglycemic effect on T2DM mice that was greater than the pumpkin polysaccharides' or the puerarin's hypoglycemic effect. Both the pumpkin polysaccharides and the puerarin were found to ameliorate the blood glucose tolerance and insulin resistance of T2DM mice. They showed lipid-lowering activity by reducing the total cholesterol, triglycerides, and low-density lipoprotein levels, and improving the high-density lipoprotein level. They had beneficial effects on the oxidative stress by decreasing the reactive oxygen species and malondialdehyde levels, and increasing the glutathione level and the superoxide dismutase activity. Furthermore, the nuclear factor E2 related factor 2 (Nrf2), heme oxygenase-1, and phosphoinositide-3-kinase (PI3K) levels were upregulated, and the Nrf2 and PI3K signalling pathways might be involved in the hypoglycemic mechanism. The combined administration of pumpkin polysaccharides and puerarin could synergistically ameliorate T2DM.
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