Evidence map›Paper›PMID 30857142›Full record

ArticleMarine drugs2019

A Synthetic Derivative of Antimicrobial Peptide Holothuroidin 2 from Mediterranean Sea Cucumber (

Maria Grazia Cusimano, Angelo Spinello, Giampaolo Barone, Domenico Schillaci, Stella Cascioferro, Alessandra Magistrato, Barbara Parrino, Vincenzo Arizza, Maria Vitale

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Maria Grazia CusimanoDipartimento di Scienze Biologiche, Chimiche e Farmaceutiche, Università di Palermo, Via Archirafi 32, 90123 Palermo, Italy. mariagrazia.cusimano@unipa.it.
Angelo SpinelloCNR-IOM-Democritos c/o International School for Advanced Studies (SISSA), Via Bonomea 265, 34136 Trieste, Italy. angelo.spinello@sissa.it.ORCID 0000-0002-8387-8956
Giampaolo BaroneDipartimento di Scienze Biologiche, Chimiche e Farmaceutiche, Università di Palermo, Via Archirafi 32, 90123 Palermo, Italy. giampaolo.barone@unipa.it.ORCID 0000-0001-8773-2359
Domenico SchillaciDipartimento di Scienze Biologiche, Chimiche e Farmaceutiche, Università di Palermo, Via Archirafi 32, 90123 Palermo, Italy. domenico.schillaci@unipa.it.
Stella CascioferroDipartimento di Scienze Biologiche, Chimiche e Farmaceutiche, Università di Palermo, Via Archirafi 32, 90123 Palermo, Italy. stellamaria.cascioferro@unipa.it.ORCID 0000-0002-4725-1881
Alessandra MagistratoCNR-IOM-Democritos c/o International School for Advanced Studies (SISSA), Via Bonomea 265, 34136 Trieste, Italy. alessandra.magistrato@sissa.it.ORCID 0000-0002-2003-1985
Barbara ParrinoDipartimento di Scienze Biologiche, Chimiche e Farmaceutiche, Università di Palermo, Via Archirafi 32, 90123 Palermo, Italy. barbara.parrino@unipa.it.
Vincenzo ArizzaDipartimento di Scienze Biologiche, Chimiche e Farmaceutiche, Università di Palermo, Via Archirafi 32, 90123 Palermo, Italy. vincenzo.arizza@unipa.it.ORCID 0000-0002-8772-7143
Maria VitaleIstituto Zooprofilattico della Sicilia, Via Gino Marinuzzi, 3, 90129 Palermo, Italy. marvitus@yahoo.com.
University of Palermo · ITScuola Internazionale Superiore di Studi Avanzati · ITIstituto Zooprofilattico Sperimentale Della Sicilia · IT

Funding

Italian Ministry of Health RC IZSI13/15 RCIZSSi 08/16
6 · The paper itself

Abstract

Due to the limited number of available antibiotics, antimicrobial peptides (AMPs) are considered antimicrobial candidates to fight difficult-to-treat infections such as those associated with biofilms. Marine environments are precious sources of AMPs, as shown by the recent discovery of antibiofilm properties of Holothuroidin 2 (H2), an AMP produced by the Mediterranean sea cucumber

Indexed as

HolothuriaAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBiofilmsDrug DesignDrug Resistance, BacterialFoodborne DiseasesListeria monocytogenesListeriosisMediterranean SeaMicrobial Sensitivity TestsMolecular Dynamics SimulationProtein Structure, TertiaryAnti-Bacterial AgentsAntimicrobial Cationic Peptidesantimicrobial peptidesbiofilmfoodborne pathogensHolothuria tubulosaListeria monocytogenes

Identifiers

PMID30857142
PMCPMC6471310
OpenAlexW2918224803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.