ArticleChild abuse & neglect2019
Fracture incidence in Ehlers-Danlos syndrome - A population-based case-control study.
Article in Child abuse & neglect, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Ehlers-Danlos Syndrome Type Arthrochalasia: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Article
- Comment on van Gemert et al. Child Abuse, Misdiagnosed by an Expertise Center-Part II-Misuse of Bayes' Theorem.Children (Basel, Switzerland) · 2024Article
- Child Abuse, Misdiagnosed by an Expertise Center-Part II-Misuse of Bayes' Theorem.Children (Basel, Switzerland) · 2023Article
- Review
- Orthopedic manifestations of child abuse.Pediatric research · 2022Review
- Fetal Fractures in an Infant with Maternal Ehlers-Danlos Syndrome, CCDC134 Pathogenic Mutation and a Negative Genetic Test for Osteogenesis Imperfecta.Children (Basel, Switzerland) · 2021Article
- Genetic causes of fractures and subdural hematomas: fact versus fiction.Pediatric radiology · 2021Review
- Abusive head trauma: neuroimaging mimics and diagnostic complexities.Pediatric radiology · 2021Review
- Ehlers-Danlos syndrome: what the radiologist needs to know.Pediatric radiology · 2021Review
- Hypermobile Ehlers-Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Bone Disease in Patients with Ehlers-Danlos Syndromes.Current osteoporosis reports · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe differential diagnosis of non-accidental injury during childhood includes medical conditions that predispose to skeletal fragility. Ehlers-Danlos syndrome (EDS) has been proposed as one such condition despite little objective evidence in the medical literature.
objectiveTo investigate if EDS causes increased bone fragility during infancy and childhood. PARTICIPANTS AND
settingResidents of an 8-county region in southern Minnesota using the Rochester Epidemiology Project (REP) medical records-linkage system.
methodsThis retrospective, population-based, case-control study identified subjects with EDS from 1976 to 2015 who had complete records for at least their first year of life. Validity of diagnosis was ascertained using the 2017 International Classification of the Ehlers-Danlos Syndromes. Records were reviewed for fracture diagnoses that were characterized by age, location, type and mechanism.
resultsOf 219 potential cases, 21 had complete records for the first year of life and sufficient evidence in the medical record to support an EDS diagnosis. Of these 21, there were 14 hypermobile, 2 classical, 4 vascular, and 1 arthrochalasia EDS subtypes. 11 of 21 EDS cases (52.4%) and 15 of 63 controls (23.8%) had one or more fractures during childhood. No fractures were identified in the first year of life. Comparing cases to controls, EDS was associated with having any fractures during childhood with an odds ratio of 3.4 (95% CI: 1.20-9.66).
conclusionsWe found no evidence that infants with common forms of EDS are predisposed to more frequent fractures. Ambulatory subjects with these EDS subtypes may have a higher incidence of fractures during childhood.
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