Evidence map›Paper›PMID 30856295›Full record

ArticleAdvanced healthcare materials2019

Biconcave Carbon Nanodisks for Enhanced Drug Accumulation and Chemo-Photothermal Tumor Therapy.

Qingxin Mu, Hui Wang, Xinyu Gu, Zachary R Stephen, Charles Yen, Fei-Chien Chang, Christopher J Dayringer, Miqin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Erythrocyte-Inspired Functional Materials for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  3. Two-dimensional-TiFrontiers in bioengineering and biotechnology · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Nano-and Micromotors Designed for Cancer Therapy.Molecules (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qingxin MuDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington, DC, 98195, USA.
Hui WangDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington, DC, 98195, USA.
Xinyu GuDepartment of Biochemistry, University of Washington Seattle, Washington, DC, 98195, USA.
Zachary R StephenDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington, DC, 98195, USA.
Charles YenDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington, DC, 98195, USA.
Fei-Chien ChangDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington, DC, 98195, USA.
Christopher J DayringerDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington, DC, 98195, USA.
Miqin ZhangDepartment of Materials Science and Engineering, University of Washington, Seattle, Washington, DC, 98195, USA.ORCID 0000-0001-8974-1494

Funding

Iron oxide nanotheranostics for breast cancerR01EB026890 · NIBIB · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2018 to 2021
$1.9M
Multifunctional nanoparticles to improve treatment of human glioblastomaR01CA161953 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2013 to 2017
$1.7M
Bruker Avance III 600 MHz (14T) Wide Bore SpectrometerS10RR029021 · NCRR · UNIVERSITY OF WASHINGTON · PI KUSHMERICK, MARTIN J · 2010 to 2010
$1.0M
Leica SP8 WWL Confocal MicroscopeS10OD016240 · OD · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 2014 to 2014
$581k
NCI NIH HHS R01 CA161953NCRR NIH HHS S10 RR029021NIBIB NIH HHS R01 EB026890NIH HHS S10 OD016240NSF NNCI-1542101
6 · The paper itself

Abstract

It is considered a significant challenge to construct nanocarriers that have high drug loading capacity and can overcome physiological barriers to deliver efficacious amounts of drugs to solid tumors. Here, the development of a safe, biconcave carbon nanodisk to address this challenge for treating breast cancer is reported. The nanodisk demonstrates fluorescent imaging capability, an exceedingly high loading capacity (947.8 mg g

Indexed as

AnimalsAntibiotics, AntineoplasticCarbonCell Line, TumorCell SurvivalCombined Modality TherapyDoxorubicinDrug Delivery SystemsFemaleHyperthermia, InducedInfrared RaysMiceMice, Inbred BALB CNanostructuresPhotochemotherapyTissue DistributionAntibiotics, AntineoplasticCarbonDoxorubicincarbon nanodiskscombination therapydrug carriersenhanced tumor accumulationphotothermal conversion

Identifiers

PMID30856295
PMCPMC6483846

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.